PMID- 16893600
OWN - NLM
STAT- MEDLINE
DCOM- 20070313
LR  - 20151119
IS  - 0301-0511 (Print)
IS  - 0301-0511 (Linking)
VI  - 74
IP  - 1
DP  - 2007 Jan
TI  - Anticipatory anxiety-induced changes in human lateral prefrontal cortex activity.
PG  - 34-8
AB  - It has been suggested that frontal brain asymmetry is associated with differences 
      in basic emotional dimensions, particularly in activation of systems underlying 
      avoidance-withdrawal behavior. We examined regional cerebral oxygenated 
      hemoglobin (O2Hb) levels in human medial prefrontal cortex (MPFC) using 
      near-infrared reflection spectroscopy (NIRS) prior to and during anticipatory 
      anxiety to determine if NIRS could detect any anxiety-related changes. Transient 
      anxiety was induced in 56 normal volunteers by anticipation and a painful shock 
      to the right-hand's median nerve. Pre- and post-anxiety affective statuses were 
      measured using the State-Trait Anxiety Inventory (STAI) and Temperature Character 
      Inventory (TCI). NIRS recorded from the left and right frontal brain regions. 
      Right MPFC O2Hb was significantly increased relative to left MPFC O2Hb during 
      anticipation of the shock. Right-sided O2Hb increases were significantly 
      correlated with the TCI Harm Avoidance subscale. These results support the 
      hypothesis that O2Hb levels in the right frontal region correlate with anxiety or 
      heightened negative affect.
FAU - Morinaga, Katsuhiko
AU  - Morinaga K
AD  - Department of Neuropsychiatry, Oita University Faculty of Medicine, Hasama-Machi, 
      Oita 879-5593, Japan.
FAU - Akiyoshi, Jotaro
AU  - Akiyoshi J
FAU - Matsushita, Hirotaka
AU  - Matsushita H
FAU - Ichioka, Shugo
AU  - Ichioka S
FAU - Tanaka, Yoshihiro
AU  - Tanaka Y
FAU - Tsuru, Jyusen
AU  - Tsuru J
FAU - Hanada, Hiroaki
AU  - Hanada H
LA  - eng
PT  - Journal Article
DEP - 20060807
PL  - Netherlands
TA  - Biol Psychol
JT  - Biological psychology
JID - 0375566
SB  - IM
MH  - Adult
MH  - Anxiety Disorders/*physiopathology/*psychology
MH  - Character
MH  - *Electroencephalography
MH  - Female
MH  - Functional Laterality/*physiology
MH  - Harm Reduction
MH  - Humans
MH  - Male
MH  - Oximetry
MH  - Personality Inventory
MH  - Prefrontal Cortex/*physiopathology
MH  - Surveys and Questionnaires
MH  - Temperature
EDAT- 2006/08/09 09:00
MHDA- 2007/03/14 09:00
CRDT- 2006/08/09 09:00
PHST- 2005/01/24 00:00 [received]
PHST- 2006/01/19 00:00 [revised]
PHST- 2006/06/20 00:00 [accepted]
PHST- 2006/08/09 09:00 [pubmed]
PHST- 2007/03/14 09:00 [medline]
PHST- 2006/08/09 09:00 [entrez]
AID - S0301-0511(06)00144-X [pii]
AID - 10.1016/j.biopsycho.2006.06.005 [doi]
PST - ppublish
SO  - Biol Psychol. 2007 Jan;74(1):34-8. doi: 10.1016/j.biopsycho.2006.06.005. Epub 
      2006 Aug 7.