PMID- 16895955
OWN - NLM
STAT- MEDLINE
DCOM- 20070112
LR  - 20151119
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 91
IP  - 11
DP  - 2006 Nov
TI  - Increased subcutaneous and epicardial adipose tissue production of 
      proinflammatory cytokines in cardiac surgery patients: possible role in 
      postoperative insulin resistance.
PG  - 4620-7
AB  - CONTEXT: Hyperglycemia and insulin resistance frequently occur in critically ill 
      patients even without a history of diabetes. OBJECTIVE: Our objective was to 
      study the role of adipose tissue hormonal production in the development of 
      insulin resistance in cardiac surgery patients. PARTICIPANTS, INTERVENTIONS, AND 
      SETTINGS: Fifteen patients with elective cardiac surgery underwent blood sampling 
      before, at the end, and 6, 12, 24, 48, and 120 h after the end of their 
      operation. Epicardial and sc adipose tissue sampling was done at the beginning 
      and at the end of surgery in the Department of Cardiac Surgery. MAIN OUTCOME 
      MEASURES: We measured serum concentrations and sc and epicardial adipose tissue 
      mRNA expression of IL-6, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, 
      leptin, resistin, and adiponectin and sc and epicardial adipose tissue mRNA 
      expression of CD14, CD45, and CD68. RESULTS: The rate of insulin infusion 
      required to maintain euglycemia increased up to 7-fold 12 h after the operation, 
      suggesting the development of insulin resistance. Serum IL-6 levels increased 
      43-fold 12 h after surgery. MCP-1 peaked 6-fold at the end of surgery. Smaller 
      peaks of TNF-alpha and leptin appeared 6 and 12 h after surgery, respectively. 
      Resistin levels peaked 4-fold 24 h after surgery, but adiponectin levels were not 
      significantly affected. TNF-alpha and CD45 mRNA expression increased markedly 
      during the operation in sc adipose tissue. IL-6, resistin, and MCP-1 mRNA 
      expression increased in both sc and epicardial adipose tissue. Leptin, 
      adiponectin, CD14, and CD68 mRNA expression did not change significantly. 
      CONCLUSIONS: Both sc and epicardial adipose tissue is a source of proinflammatory 
      cytokines in cardiac surgery patients and may contribute to the development of 
      postoperative insulin resistance.
FAU - Kremen, Jaromir
AU  - Kremen J
AD  - Third Department of Medicine, First Faculty of Medicine, Charles University, U 
      Nemocnice 1, 128 08, Prague 2, Czech Republic.
FAU - Dolinkova, Marketa
AU  - Dolinkova M
FAU - Krajickova, Jana
AU  - Krajickova J
FAU - Blaha, Jan
AU  - Blaha J
FAU - Anderlova, Katerina
AU  - Anderlova K
FAU - Lacinova, Zdena
AU  - Lacinova Z
FAU - Haluzikova, Denisa
AU  - Haluzikova D
FAU - Bosanska, Lenka
AU  - Bosanska L
FAU - Vokurka, Martin
AU  - Vokurka M
FAU - Svacina, Stepan
AU  - Svacina S
FAU - Haluzik, Martin
AU  - Haluzik M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060808
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Cytokines)
RN  - 0 (Hormones)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Insulin)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adipose Tissue, White/*metabolism
MH  - Aged
MH  - Anti-Inflammatory Agents/blood/metabolism
MH  - Biomarkers/blood
MH  - Blood Glucose/analysis
MH  - Cytokines/*biosynthesis/physiology
MH  - Female
MH  - Hormones/blood/metabolism
MH  - Humans
MH  - Hyperglycemia/blood/drug therapy/etiology
MH  - Immunocompetence/physiology
MH  - Inflammation Mediators/*metabolism/physiology
MH  - Infusion Pumps
MH  - Insulin/administration & dosage/blood
MH  - Insulin Resistance/*physiology
MH  - Male
MH  - Middle Aged
MH  - Pericardium/*cytology
MH  - Postoperative Period
MH  - RNA, Messenger/metabolism
MH  - Subcutaneous Fat/*metabolism
MH  - *Thoracic Surgery
EDAT- 2006/08/10 09:00
MHDA- 2007/01/16 09:00
CRDT- 2006/08/10 09:00
PHST- 2006/08/10 09:00 [pubmed]
PHST- 2007/01/16 09:00 [medline]
PHST- 2006/08/10 09:00 [entrez]
AID - jc.2006-1044 [pii]
AID - 10.1210/jc.2006-1044 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2006 Nov;91(11):4620-7. doi: 10.1210/jc.2006-1044. Epub 
      2006 Aug 8.