PMID- 16896169
OWN - NLM
STAT- MEDLINE
DCOM- 20070216
LR  - 20071203
IS  - 0193-1849 (Print)
IS  - 0193-1849 (Linking)
VI  - 292
IP  - 1
DP  - 2007 Jan
TI  - Influences of calorie restriction and age on energy expenditure in the rhesus 
      monkey.
PG  - E101-6
AB  - Caloric restriction (CR) is known to retard the aging process, and a marker of 
      aging is decreased energy expenditure (EE). To assess longitudinal effects of CR 
      on EE in rhesus monkeys (Macaca mulatta), data from 41 males (M) and 26 females 
      (F) subjected to 9 or 15 yr of CR were studied. EE and body composition of 
      monkeys 11-28 yr of age were measured using indirect calorimetry and dual X-ray 
      absorptiometry. Total EE (24-h EE) was divided into daytime (day EE), nighttime 
      (night EE), and daytime minus nighttime (D - N EE). M calorie-restricted monkeys 
      showed a lower 24-h EE (means +/- SD = 568 +/- 96 kcal/day, P < 0.0001) than 
      controls (C; 630 +/- 129 kcal/day). Calorie-restricted M had a lower night EE 
      (difference = 36 kcal P < 0.0001) compared with C M, but after adjusting for FFM 
      and FM, night EE was not different between calorie-restricted and C males (P = 
      0.72). The 24-h EE decreased with age (13 kcal decrease/yr, P < 0.0001), but 
      there was no difference between CR and C. Adjusted for FFM and FM, D - N EE 
      decreased with age (9 kcal/yr, P < 0.0001), with no interaction with age (P = 
      0.72). The F were compared with age-matched M selected from the male cohort. F 
      had a lower 24-h EE (496 +/- 84 kcal/day) than M (636 +/- 139 kcal/day) (P < 
      0.0001). Adjusting for FFM and FM, night EE was lower in F compared with M 
      (difference = 18 kcal, P = 0.077). Night EE did not differ between 
      calorie-restricted and C younger monkeys after adjusting for FFM and FM. In 
      conclusion, CR did not alter the age-related decrease in EE with CR.
FAU - Raman, Aarthi
AU  - Raman A
AD  - Nutritional Sciences, Univ. of Wisconsin-Madison, 1415 Linden Dr., Madison, WI 
      53607, USA. dschoell@nutrisci.wisc.edu
FAU - Ramsey, Jon J
AU  - Ramsey JJ
FAU - Kemnitz, Joseph W
AU  - Kemnitz JW
FAU - Baum, Scott T
AU  - Baum ST
FAU - Newton, Wendy
AU  - Newton W
FAU - Colman, Ricki J
AU  - Colman RJ
FAU - Weindruch, Richard
AU  - Weindruch R
FAU - Beasley, Mark T
AU  - Beasley MT
FAU - Schoeller, Dale A
AU  - Schoeller DA
LA  - eng
GR  - P01-AG-11915/AG/NIA NIH HHS/United States
GR  - P51-RR-000167/RR/NCRR NIH HHS/United States
GR  - RR-020141-01/RR/NCRR NIH HHS/United States
GR  - RR-15459-01/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060808
PL  - United States
TA  - Am J Physiol Endocrinol Metab
JT  - American journal of physiology. Endocrinology and metabolism
JID - 100901226
SB  - IM
MH  - Age Factors
MH  - Aging/*physiology
MH  - Animals
MH  - *Caloric Restriction
MH  - Circadian Rhythm
MH  - Energy Metabolism/*physiology
MH  - Female
MH  - Macaca mulatta
MH  - Male
MH  - Sex Characteristics
MH  - Time
EDAT- 2006/08/10 09:00
MHDA- 2007/02/17 09:00
CRDT- 2006/08/10 09:00
PHST- 2006/08/10 09:00 [pubmed]
PHST- 2007/02/17 09:00 [medline]
PHST- 2006/08/10 09:00 [entrez]
AID - 00127.2006 [pii]
AID - 10.1152/ajpendo.00127.2006 [doi]
PST - ppublish
SO  - Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E101-6. doi: 
      10.1152/ajpendo.00127.2006. Epub 2006 Aug 8.