PMID- 16897598
OWN - NLM
STAT- MEDLINE
DCOM- 20071004
LR  - 20181113
IS  - 0300-9564 (Print)
IS  - 0300-9564 (Linking)
VI  - 114
IP  - 4
DP  - 2007
TI  - Levels of neurotrophic factors in the hippocampus and amygdala correlate with 
      anxiety- and fear-related behaviour in C57BL6 mice.
PG  - 431-44
AB  - The present study tested whether individual differences in anxiety- and 
      fear-related behaviour are associated with between-subjects variation in 
      postmortem brain levels of selected neurotrophic factors. Naive C57BL6/J mice of 
      both sexes were subjected either to an elevated plus maze test or to a Pavlovian 
      fear conditioning paradigm. Two days after behavioural assays, the mice were 
      sacrificed for postmortem quantification of the protein levels of brain derived 
      neurotrophic factors (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3) 
      in the hippocampus and amygdala. Significant correlations between behavioural 
      measures and postmortem regional neurotrophic factor contents were revealed. The 
      magnitude of anxiety-like behaviour in the elevated plus maze was positively 
      related to dorsal hippocampal BDNF levels, but negatively related to NGF levels 
      in dorsal hippocampus and in the amygdala. On the other hand, the expression of 
      conditioned fear is positively related to amygdala BDNF and NGF levels, and to 
      dorsal hippocampal NGF levels. Our results add to existing reports in human as 
      well as in animals of correlation between anxiety trait and gross measures of 
      hippocampal volume or activation levels. Moreover, a distinction between 
      spontaneous and learned (or conditioned) anxiety/fear would be relevant to the 
      identification of neurotrophin signalling mechanisms in the hippocampus and 
      amygdala implicated in anxiety and related psychopathology.
FAU - Yee, B K
AU  - Yee BK
AD  - Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology 
      Zurich, Schwerzenbach, Switzerland. byee@ethz.ch
FAU - Zhu, S-W
AU  - Zhu SW
FAU - Mohammed, A H
AU  - Mohammed AH
FAU - Feldon, J
AU  - Feldon J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060808
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Amygdala/chemistry/*metabolism
MH  - Animals
MH  - Anxiety/*metabolism
MH  - Behavior, Animal/physiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fear/*physiology
MH  - Female
MH  - Hippocampus/chemistry/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nerve Growth Factors/analysis/*metabolism
MH  - Sex Factors
EDAT- 2006/08/10 09:00
MHDA- 2007/10/05 09:00
CRDT- 2006/08/10 09:00
PHST- 2006/03/19 00:00 [received]
PHST- 2006/06/23 00:00 [accepted]
PHST- 2006/08/10 09:00 [pubmed]
PHST- 2007/10/05 09:00 [medline]
PHST- 2006/08/10 09:00 [entrez]
AID - 10.1007/s00702-006-0548-9 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2007;114(4):431-44. doi: 10.1007/s00702-006-0548-9. 
      Epub 2006 Aug 8.