PMID- 16899054
OWN - NLM
STAT- MEDLINE
DCOM- 20070817
LR  - 20070523
IS  - 1601-1848 (Print)
IS  - 1601-183X (Linking)
VI  - 6
IP  - 4
DP  - 2007 Jun
TI  - Genetic variation in the hypothalamic-pituitary-adrenocortical axis regulatory 
      factor, T-box 19, and the angry/hostility personality trait.
PG  - 321-8
AB  - Neurotic personality traits are important factors in several psychiatric 
      disorders and suicidal behavior. Here, we have investigated the existence of 
      potential relationships between neurotic personality traits and genetic 
      variation. Non-suicidal parents derived from trios (suicide attempter and both 
      parents) and non-suicidal volunteers, examined by the Neuroticism, Extraversion 
      and Openness (NEO) Personality Inventory - Revised (NEO PI-R), were divided into 
      screening and replication samples. The screening sample (n= 127) was used to 
      select potential relationships between neurotic personality traits and genetic 
      variation among 130 single nucleotide polymorphisms (SNPs). Screening (analysis 
      of variance) with regard to the personality dimension neuroticism indicated 
      potential relationships at three different loci. More detailed analysis of these 
      three SNPs at NEO PI-R facet level indicated four potential relationships. T-test 
      analysis in the replication sample (n= 617) was used to retest the relationships 
      indicated during screening. One of those relationships was confirmed in the 
      replication sample (P= 0.0052; Bonferroni correction), indicating that genetic 
      variation at the human T-box 19 (TBX19) locus is related to the personality trait 
      angry/hostility. Furthermore, using analysis of haplotypes among trios by 
      transmission disequilibrium test and its extension, the family-based association 
      test, overtransmission of a haplotype GAC at the TBX19 locus was associated with 
      increased angry/hostility scores among suicide attempters (P= 0.009; Bonferroni 
      correction). This is to our knowledge the first report on the association of the 
      angry hostility personality trait with genetic variation at the TBX19 locus, an 
      important regulator of the hypothalamic-pituitary-adrenocortical axis.
FAU - Wasserman, D
AU  - Wasserman D
AD  - The National and the Stockholm County Centre for Suicide Research and Prevention 
      of Mental Ill-Health (NASP) at the Department of Public Health Sciences, 
      Karolinska Institute (KI), Stockholm, Sweden. danuta.wasserman@ki.se
FAU - Geijer, T
AU  - Geijer T
FAU - Sokolowski, M
AU  - Sokolowski M
FAU - Rozanov, V
AU  - Rozanov V
FAU - Wasserman, J
AU  - Wasserman J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060807
PL  - England
TA  - Genes Brain Behav
JT  - Genes, brain, and behavior
JID - 101129617
RN  - 0 (Genetic Markers)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (TBX19 protein, human)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Anger/*physiology
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Markers/genetics
MH  - Haplotypes/genetics
MH  - Homeodomain Proteins/*genetics/physiology
MH  - *Hostility
MH  - Humans
MH  - Hypothalamo-Hypophyseal System/physiology
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Neurotic Disorders/*genetics/physiopathology
MH  - Pedigree
MH  - Personality/*genetics
MH  - Pituitary-Adrenal System/physiology
MH  - Polymorphism, Single Nucleotide
MH  - Statistics, Nonparametric
MH  - *Suicide, Attempted
MH  - T-Box Domain Proteins/*genetics/physiology
EDAT- 2006/08/11 09:00
MHDA- 2007/08/19 09:00
CRDT- 2006/08/11 09:00
PHST- 2006/08/11 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2006/08/11 09:00 [entrez]
AID - GBB259 [pii]
AID - 10.1111/j.1601-183X.2006.00259.x [doi]
PST - ppublish
SO  - Genes Brain Behav. 2007 Jun;6(4):321-8. doi: 10.1111/j.1601-183X.2006.00259.x. 
      Epub 2006 Aug 7.