PMID- 16899197
OWN - NLM
STAT- MEDLINE
DCOM- 20061222
LR  - 20191110
IS  - 1529-7322 (Print)
IS  - 1529-7322 (Linking)
VI  - 6
IP  - 5
DP  - 2006 Sep
TI  - Interleukin-10-secreting regulatory T cells in allergy and asthma.
PG  - 363-71
AB  - Allergic diseases, including asthma, are chronic inflammatory disorders 
      originating from an aberrant immune response to innocuous antigens in our 
      environment (allergens). In susceptible individuals, sensitization to allergen 
      leads to the induction of allergen-specific T-helper type 2 (Th2) responses and 
      immunoglobulin E (IgE) production. Subsequent challenge with allergen results in 
      IgE-mediated mast cell activation and the recruitment and activation of effector 
      cells, leading to clinical symptoms of disease. In this review, we discuss 
      evidence that the anti-inflammatory cytokine interleukin-10 (IL-10) offers 
      therapeutic promise for the control of asthma and allergy. We highlight the 
      potential role of IL-10 secretion by a specialized T-cell subset, T regulatory 
      cells, to prevent allergic inflammation in healthy individuals and to provide 
      long-term relief from disease symptoms in allergic patients.
FAU - Urry, Zoe
AU  - Urry Z
AD  - Kings College London, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, 
      Department of Asthma,Allergy and Respiratory Science, 5th Floor Thomas Guy House, 
      Guy's Hospital, London SE1 9RT, UK.
FAU - Xystrakis, Emmanuel
AU  - Xystrakis E
FAU - Hawrylowicz, Catherine M
AU  - Hawrylowicz CM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - Asthma/*immunology
MH  - Disease Models, Animal
MH  - Homeostasis
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Inflammation/immunology
MH  - Interleukin-10/immunology
MH  - Lung/immunology
MH  - T-Lymphocytes, Regulatory/immunology
RF  - 60
EDAT- 2006/08/11 09:00
MHDA- 2006/12/23 09:00
CRDT- 2006/08/11 09:00
PHST- 2006/08/11 09:00 [pubmed]
PHST- 2006/12/23 09:00 [medline]
PHST- 2006/08/11 09:00 [entrez]
AID - 10.1007/s11882-996-0005-8 [doi]
PST - ppublish
SO  - Curr Allergy Asthma Rep. 2006 Sep;6(5):363-71. doi: 10.1007/s11882-996-0005-8.