PMID- 16899296
OWN - NLM
STAT- MEDLINE
DCOM- 20070108
LR  - 20131121
IS  - 0162-0134 (Print)
IS  - 0162-0134 (Linking)
VI  - 100
IP  - 11
DP  - 2006 Nov
TI  - Interactions of 1,12-diamino-4,9-dioxadodecane (OSpm) and Cu(II) ions with 
      pyrimidine and purine nucleotides: adenosine-5'-monophosphate (AMP) and 
      cytidine-5'-monophosphate (CMP).
PG  - 1781-9
AB  - The interactions of Cu(II) ions with adenosine-5'-monophosphate (AMP), 
      cytidine-5'-monophosphate (CMP) and 1,12-diamino-4,9-dioxadodecane (OSpm) were 
      studied. A potentiometric method was applied to determine the composition and 
      stability constants of complexes formed, while the mode of interactions was 
      analysed by spectral methods (ultraviolet and visible spectroscopy (UV-Vis), 
      electron paramagnetic resonance (EPR), (13)C NMR, (31)P NMR). In metal-free 
      systems, molecular complexes nucleotide-polyamine (NMP)H(x)(OSpm) were formed. 
      The endocyclic nitrogen atoms of the purine ring N(1), N(7), the nitrogen atom of 
      the pyrimidine ring N(3), the oxygen atoms of the phosphate group of the 
      nucleotide and the protonated nitrogen atoms of the polyamine were the reaction 
      centres. The mode of interaction of the metal ion with OSpm and the nucleotides 
      (AMP or CMP) in the coordination compounds was established. In the system 
      Cu(II)/OSpm the dinuclear complex Cu(2)(OSpm) forms, while in the ternary systems 
      Cu(II)/nucleotide/OSpm the species type MH(x)LL' and MLL' appear. In the MH(x)LL' 
      type species, the main centres of copper (II) ion binding in the nucleotide are 
      the phosphate groups. The protonated amino groups of OSpm are involved in 
      non-covalent interaction with the nitrogen atoms N(1), N(7) or N(3) of the purine 
      or pyrimidine ring, whereas at higher pH, deprotonated nitrogen atoms of 
      polyamine are engaged in metallation in MLL' species.
FAU - Lomozik, L
AU  - Lomozik L
AD  - Faculty of Chemistry, A. Mickiewicz University, Grunwaldzka 6, 60-780 Poznan, 
      Poland. lomozik@amu.edu.pl <lomozik@amu.edu.pl>
FAU - Gasowska, A
AU  - Gasowska A
FAU - Krzysko, G
AU  - Krzysko G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060704
PL  - United States
TA  - J Inorg Biochem
JT  - Journal of inorganic biochemistry
JID - 7905788
RN  - 0 (Purine Nucleotides)
RN  - 0 (Pyrimidine Nucleotides)
RN  - 2FZ7Y3VOQX (Spermine)
RN  - 415SHH325A (Adenosine Monophosphate)
RN  - 789U1901C5 (Copper)
RN  - F469818O25 (Cytidine Monophosphate)
SB  - IM
MH  - Adenosine Monophosphate/chemistry
MH  - Copper/*chemistry
MH  - Cytidine Monophosphate/*chemistry
MH  - Drug Interactions
MH  - Electron Spin Resonance Spectroscopy
MH  - Hydrogen-Ion Concentration
MH  - Magnetic Resonance Spectroscopy
MH  - Molecular Structure
MH  - Purine Nucleotides/*chemistry
MH  - Pyrimidine Nucleotides/*chemistry
MH  - Spermine/analogs & derivatives/chemistry
EDAT- 2006/08/11 09:00
MHDA- 2007/01/09 09:00
CRDT- 2006/08/11 09:00
PHST- 2006/04/14 00:00 [received]
PHST- 2006/06/21 00:00 [revised]
PHST- 2006/06/25 00:00 [accepted]
PHST- 2006/08/11 09:00 [pubmed]
PHST- 2007/01/09 09:00 [medline]
PHST- 2006/08/11 09:00 [entrez]
AID - S0162-0134(06)00191-7 [pii]
AID - 10.1016/j.jinorgbio.2006.06.009 [doi]
PST - ppublish
SO  - J Inorg Biochem. 2006 Nov;100(11):1781-9. doi: 10.1016/j.jinorgbio.2006.06.009. 
      Epub 2006 Jul 4.