PMID- 16900733
OWN - NLM
STAT- MEDLINE
DCOM- 20060911
LR  - 20181201
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 145
IP  - 7
DP  - 2006 Jul
TI  - [Subacute cutaneous lupus erythematosus induced by terbinafine].
PG  - 480-2, 552
AB  - BACKGROUND: The onset of subacute cutaneous lupus erythematosus (SCLE) may be 
      associated with the administration of a variety of drugs. Terbinafine, an oral 
      antifungal agent, which rarely causes cutaneous eruptions, has been implicated as 
      the cause or exacerbation of cutaneous lupus erythematosus in several patients. 
      CASE: A 59-year-old man had received oral terbinafine for onychomycosis. The 
      patient had a history of SCLE, which was in complete remission during the last 5 
      years. A month after initiating treatment with terbinafine the patient developed 
      SCLE, which was diagnosed clinically and by histology. He had typical 
      papulosquamous lesions. Immunological studies showed elevated titers of 
      anti-nuclear antibodies. Following discontinuation of terbinafine therapy and 
      under the treatment of systemic and topical steroids, a slow resolution of the 
      eruption was noted over several weeks. CONCLUSIONS: This report, along with 
      previous cases described, suggests the association between terbinafine therapy 
      and the onset or exacerbation of SCLE often occurring in a patient with history 
      of systemic lupus erythematosus or SCLE.
FAU - Amitay-Layish, Iris
AU  - Amitay-Layish I
AD  - Department of Dermatology, Rabin Medical Center, Petah Tikva, Israel. 
      amitay2@zahav.net.il
FAU - Feuerman, Hana
AU  - Feuerman H
FAU - David, Michael
AU  - David M
LA  - heb
PT  - Case Reports
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Naphthalenes)
RN  - 0 (Trypanocidal Agents)
RN  - G7RIW8S0XP (Terbinafine)
SB  - IM
MH  - Antibodies, Antinuclear/blood
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*chemically induced/immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - Naphthalenes/*adverse effects
MH  - Onychomycosis/*drug therapy
MH  - Recurrence
MH  - Terbinafine
MH  - Trypanocidal Agents/*adverse effects
EDAT- 2006/08/12 09:00
MHDA- 2006/09/12 09:00
CRDT- 2006/08/12 09:00
PHST- 2006/08/12 09:00 [pubmed]
PHST- 2006/09/12 09:00 [medline]
PHST- 2006/08/12 09:00 [entrez]
PST - ppublish
SO  - Harefuah. 2006 Jul;145(7):480-2, 552.