PMID- 1690126
OWN - NLM
STAT- MEDLINE
DCOM- 19900420
LR  - 20220511
IS  - 0261-4189 (Print)
IS  - 1460-2075 (Electronic)
IS  - 0261-4189 (Linking)
VI  - 9
IP  - 3
DP  - 1990 Mar
TI  - The int-2 gene product acts as an epithelial growth factor in transgenic mice.
PG  - 907-13
AB  - The induction of mammary tumors by mouse mammary tumor virus (MMTV) is thought to 
      occur through proviral activation of one or more cellular genes. One of these, 
      int-2, encodes a 27 kd protein which exhibits striking homology to the basic 
      fibroblast growth factor family. To assess directly the role of the int-2 protein 
      in cell proliferation, we have established transgenic mice which carry the int-2 
      gene driven by the MMTV promoter/enhancer. Expression of the int-2 gene in female 
      transgenic mice results in pronounced mammary gland hyperplasia. Interestingly, 
      expression of the MMTV-int-2 transgene in the prostate gland of male carriers 
      results in a benign, but dramatic, epithelial hyperplasia similar to benign 
      prostatic hypertrophy (BPH), a common but poorly understood disorder in human 
      populations. Together, these results indicate that the int-2 product can act as a 
      potent growth factor in these epithelial tissues.
FAU - Muller, W J
AU  - Muller WJ
AD  - Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, 
      Boston, MA 02115.
FAU - Lee, F S
AU  - Lee FS
FAU - Dickson, C
AU  - Dickson C
FAU - Peters, G
AU  - Peters G
FAU - Pattengale, P
AU  - Pattengale P
FAU - Leder, P
AU  - Leder P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (DNA, Viral)
RN  - 0 (Fgf3 protein, mouse)
RN  - 0 (Fibroblast Growth Factor 3)
RN  - 0 (Growth Substances)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Animals
MH  - DNA, Viral/genetics
MH  - Female
MH  - Fibroblast Growth Factor 3
MH  - *Fibroblast Growth Factors
MH  - *Gene Expression
MH  - Genetic Vectors
MH  - Growth Substances/*genetics
MH  - Male
MH  - Mammary Glands, Animal/microbiology/pathology
MH  - Mammary Tumor Virus, Mouse/*genetics/isolation & purification
MH  - Mice
MH  - Mice, Transgenic
MH  - Prostate/microbiology/pathology
MH  - Prostatic Hyperplasia/microbiology/pathology
MH  - Proto-Oncogene Proteins/*genetics/physiology
MH  - Restriction Mapping
PMC - PMC551751
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
PMCR- 1991/03/01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
PHST- 1991/03/01 00:00 [pmc-release]
AID - 10.1002/j.1460-2075.1990.tb08188.x [doi]
PST - ppublish
SO  - EMBO J. 1990 Mar;9(3):907-13. doi: 10.1002/j.1460-2075.1990.tb08188.x.