PMID- 16901635
OWN - NLM
STAT- MEDLINE
DCOM- 20061103
LR  - 20221207
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 406
IP  - 1-2
DP  - 2006 Oct 2
TI  - The 196G/A (val66met) polymorphism of the BDNF gene is significantly associated 
      with binge eating behavior in women with bulimia nervosa or binge eating 
      disorder.
PG  - 133-7
AB  - The brain-derived neurotrophic factor (BDNF) is involved not only in promoting 
      neuronal outgrowth and differentiation, synaptic connectivity and neuronal 
      repair, but also in modulating eating behavior. Since genetic factors likely 
      contribute to the biological vulnerability to bulimia nervosa (BN) and binge 
      eating disorder (BED), we investigated whether the functional 196G/A single 
      nucleotide polymorphism (SNP) of the BDNF gene was associated to BN and/or BED or 
      to some phenotypic aspects of the disordered eating. Two hundred and ten 
      Caucasian women (126 with BN, 84 with BED and 121 healthy controls) participated 
      into the study. No significant differences were found in the frequencies of the 
      196G/A variants of the BDNF gene among patients with BN or BED and healthy 
      controls. In both BN and BED groups, subjects carrying the 196A/A genotype 
      exhibited a weekly frequency of bingeing and a severity of binge eating (as 
      assessed by the Bulimia Investigation Test Edinburgh) significantly higher than 
      those with the 196A/G and 196G/G genotypes. These results suggest that the 196G/A 
      SNP of the human BDNF gene does not contribute to the genetic susceptibility to 
      BN and BED, but may predispose those patients to a more severe binge eating 
      behavior.
FAU - Monteleone, Palmiero
AU  - Monteleone P
AD  - Department of Psychiatry, University of Naples SUN, Italy. monteri@tin.it
FAU - Zanardini, Roberta
AU  - Zanardini R
FAU - Tortorella, Alfonso
AU  - Tortorella A
FAU - Gennarelli, Massimo
AU  - Gennarelli M
FAU - Castaldo, Eloisa
AU  - Castaldo E
FAU - Canestrelli, Benedetta
AU  - Canestrelli B
FAU - Maj, Mario
AU  - Maj M
LA  - eng
PT  - Journal Article
DEP - 20060809
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Amino Acid Substitution/genetics
MH  - Brain/*metabolism/physiopathology
MH  - Brain Chemistry/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Bulimia Nervosa/*genetics/*metabolism/physiopathology
MH  - DNA Mutational Analysis
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Testing
MH  - Genotype
MH  - Humans
MH  - Methionine/metabolism
MH  - Mutation/genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Valine/metabolism
MH  - White People/genetics
EDAT- 2006/08/12 09:00
MHDA- 2006/11/04 09:00
CRDT- 2006/08/12 09:00
PHST- 2006/06/08 00:00 [received]
PHST- 2006/07/08 00:00 [revised]
PHST- 2006/07/17 00:00 [accepted]
PHST- 2006/08/12 09:00 [pubmed]
PHST- 2006/11/04 09:00 [medline]
PHST- 2006/08/12 09:00 [entrez]
AID - S0304-3940(06)00738-5 [pii]
AID - 10.1016/j.neulet.2006.07.040 [doi]
PST - ppublish
SO  - Neurosci Lett. 2006 Oct 2;406(1-2):133-7. doi: 10.1016/j.neulet.2006.07.040. Epub 
      2006 Aug 9.