PMID- 16901952
OWN - NLM
STAT- MEDLINE
DCOM- 20070119
LR  - 20071203
IS  - 0379-864X (Print)
IS  - 0379-864X (Linking)
VI  - 31
IP  - 8
DP  - 2006 Oct
TI  - Sexual experience does not compensate for the disruptive effects of zinc 
      sulfate--lesioning of the main olfactory epithelium on sexual behavior in male 
      mice.
PG  - 753-62
AB  - Recent studies point to an important role for the main olfactory epithelium (MOE) 
      in regulating sexual behavior in male mice. We asked whether sexual experience 
      could compensate for the disruptive effects of lesioning the MOE on sexual 
      behavior in male mice. Male mice, which were either sexually naive or 
      experienced, received an intranasal irrigation of either a zinc sulfate solution 
      to destroy the MOE or saline. Sexual behavior in mating tests with an estrous 
      female was completely abolished in zinc sulfate-treated male mice regardless of 
      whether subjects were sexually experienced or not before the treatment. 
      Furthermore, zinc sulfate treatment clearly disrupted olfactory investigation of 
      both volatile and nonvolatile odors. Destruction of the MOE by zinc sulfate 
      treatment was confirmed by a significant reduction in the expression of Fos 
      protein in the main olfactory bulb following exposure to estrous female urine. By 
      contrast, vomeronasal function did not seem to be affected by zinc sulfate 
      treatment: nasal application of estrous female urine induced similar levels of 
      Fos protein in the mitral and granule cells of the accessory olfactory bulb (AOB) 
      of zinc sulfate- and saline-treated males. Likewise, the expression of soybean 
      agglutinin, which stains the axons of vomeronasal organ neurons projecting to the 
      glomerular layer of the AOB, was similar in zinc sulfate- and saline-treated male 
      mice. These results show that the main olfactory system is essential for the 
      expression of sexual behavior in male mice and that sexual experience does not 
      overcome the disruptive effects of MOE lesioning on this behavior.
FAU - Keller, Matthieu
AU  - Keller M
AD  - Center for Cellular and Molecular Neurobiology, Boulevard de l'Hopital 1, B-36, 
      B-4000 Liege Sart Tilman, Belgium.
FAU - Douhard, Quentin
AU  - Douhard Q
FAU - Baum, Michael J
AU  - Baum MJ
FAU - Bakker, Julie
AU  - Bakker J
LA  - eng
GR  - HD044897/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20060810
PL  - England
TA  - Chem Senses
JT  - Chemical senses
JID - 8217190
RN  - 7733-02-0 (Zinc Sulfate)
SB  - IM
MH  - Animals
MH  - Axons/*drug effects/physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Olfactory Mucosa/cytology/*drug effects/physiology
MH  - Sexual Behavior, Animal/*drug effects/physiology
MH  - Vomeronasal Organ/cytology/*drug effects/physiology
MH  - Zinc Sulfate/adverse effects/*pharmacology
EDAT- 2006/08/12 09:00
MHDA- 2007/01/20 09:00
CRDT- 2006/08/12 09:00
PHST- 2006/08/12 09:00 [pubmed]
PHST- 2007/01/20 09:00 [medline]
PHST- 2006/08/12 09:00 [entrez]
AID - bjl018 [pii]
AID - 10.1093/chemse/bjl018 [doi]
PST - ppublish
SO  - Chem Senses. 2006 Oct;31(8):753-62. doi: 10.1093/chemse/bjl018. Epub 2006 Aug 10.