PMID- 16903871
OWN - NLM
STAT- MEDLINE
DCOM- 20061220
LR  - 20141120
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 99
IP  - 3
DP  - 2006 Nov
TI  - Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating 
      abnormality induced by postnatal exposure to phencyclidine: comparison with adult 
      treatment.
PG  - 770-80
AB  - Brain-derived neurotrophic factor (BDNF) is involved in synaptic development and 
      plasticity, and alterations in BDNF expression or signaling are implicated in 
      drug addiction and psychiatric diseases, such as depression and schizophrenia. In 
      this study, we administered phencyclidine to postnatal and adult rats with 
      different time schedules, and determined the correlations between BDNF expression 
      and the behavioral effects. Both single and repeated phencyclidine injections 
      into adult rats induced BDNF up-regulation in the corticolimbic system and a 
      decrease in prepulse inhibition, both of which were transient. In contrast, 
      subchronic postnatal administration increased BDNF protein and mRNA levels in the 
      hippocampus and entorhinal cortex, which were sustained until 8 weeks of age. In 
      parallel, the postnatal rats treated with phencyclidine developed a persistent 
      decrease in prepulse inhibition at the adult stage. The chronic BDNF increase 
      appeared to contribute to the prepulse inhibition abnormality, as subchronic BDNF 
      infusion into the hippocampus of normal rats mimicked the prepulse inhibition 
      deficits. This study suggests that phencyclidine exposure during brain 
      development induces sustained BDNF up-regulation in the limbic system with a 
      biological link to sensorimotor gating deficits.
FAU - Takahashi, Makoto
AU  - Takahashi M
AD  - Department of Psychiatry, Niigata University Graduate School of Medical and 
      Dental Sciences, Niigata, Japan.
FAU - Kakita, Akiyoshi
AU  - Kakita A
FAU - Futamura, Takashi
AU  - Futamura T
FAU - Watanabe, Yuichiro
AU  - Watanabe Y
FAU - Mizuno, Makoto
AU  - Mizuno M
FAU - Sakimura, Kenji
AU  - Sakimura K
FAU - Castren, Eero
AU  - Castren E
FAU - Nabeshima, Toshitaka
AU  - Nabeshima T
FAU - Someya, Toshiyuki
AU  - Someya T
FAU - Nawa, Hiroyuki
AU  - Nawa H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060811
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Hallucinogens)
RN  - 0 (NR1 NMDA receptor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - J1DOI7UV76 (Phencyclidine)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Animals, Newborn/physiology
MH  - Blotting, Northern
MH  - Blotting, Western
MH  - Brain/pathology
MH  - Brain Chemistry/drug effects
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/pharmacology/*physiology
MH  - Hallucinogens/*pharmacology
MH  - Hippocampus
MH  - Immunoenzyme Techniques
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Microinjections
MH  - Phencyclidine/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, N-Methyl-D-Aspartate/biosynthesis/drug effects/genetics
MH  - Reflex, Startle/*drug effects
MH  - Signal Transduction/drug effects
MH  - Up-Regulation/drug effects/physiology
EDAT- 2006/08/15 09:00
MHDA- 2006/12/21 09:00
CRDT- 2006/08/15 09:00
PHST- 2006/08/15 09:00 [pubmed]
PHST- 2006/12/21 09:00 [medline]
PHST- 2006/08/15 09:00 [entrez]
AID - JNC4106 [pii]
AID - 10.1111/j.1471-4159.2006.04106.x [doi]
PST - ppublish
SO  - J Neurochem. 2006 Nov;99(3):770-80. doi: 10.1111/j.1471-4159.2006.04106.x. Epub 
      2006 Aug 11.