PMID- 16904252 OWN - NLM STAT- MEDLINE DCOM- 20070315 LR - 20230817 IS - 0278-5846 (Print) IS - 0278-5846 (Linking) VI - 31 IP - 1 DP - 2007 Jan 30 TI - Low plasma BDNF is associated with suicidal behavior in major depression. PG - 78-85 AB - Brain-derived neurotrophic factor (BDNF), the most abundant neurotrophin in the brain, has a known association with the pathophysiology of anxiety and depression. However, the role of BDNF in suicide has not been well investigated to date. This study examined plasma BDNF levels in 32 major depressive disorder (MDD) patients who had recently attempted suicide, 32 non-suicidal MDD patients, and 30 normal controls. The lethality of the suicide attempt was measured using the Risk-Rescue Rating (RRR) and Lethality Suicide Attempt Rating Scale (LSARS). The severity of depression was measured with the Hamilton Depression Rating Scale (HDRS). Plasma BDNF levels were measured by enzyme linked immunosorbent assay. BDNF levels were significantly lower in suicidal MDD patients (430.5+/-397.0 pg/ml) than non-suicidal MDD patients (875.80+/-663.02 pg/ml) or normal controls (889.4+/-611.3 pg/ml) (F=6.682, p=0.002). The most suitable cut-off point of BDNF level between suicidal depression and non-suicidal depression groups was 444.58 pg/ml. At this cut-off point, the sensitivity=68.7%, specificity=78.1%, positive predictive value=75.9%, and negative predictive value=71.4%. However, there was no significant difference in BDNF levels between the depressive control and normal control groups (p=0.996). LSARS and RRR did not reveal any significant correlations with BDNF levels in suicidal patients. In addition, BDNF levels were not different between fatal and non-fatal suicide attempts. These results suggest that reduction of plasma BDNF level is related to suicidal behavior in major depression and that BDNF level may be a biological marker of suicidal depression. FAU - Kim, Yong-Ku AU - Kim YK AD - Department of Psychiatry, College of Medicine, Korea University, Korea. yongku@korea.ac.kr FAU - Lee, Heung-Pyo AU - Lee HP FAU - Won, Sung-Doo AU - Won SD FAU - Park, Eun-Young AU - Park EY FAU - Lee, Hwa-Young AU - Lee HY FAU - Lee, Bun-Hee AU - Lee BH FAU - Lee, Sung-Woo AU - Lee SW FAU - Yoon, Dokyung AU - Yoon D FAU - Han, Changsu AU - Han C FAU - Kim, Dai-Jin AU - Kim DJ FAU - Choi, So-Hyun AU - Choi SH LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20060810 PL - England TA - Prog Neuropsychopharmacol Biol Psychiatry JT - Progress in neuro-psychopharmacology & biological psychiatry JID - 8211617 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM CIN - Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):578-9; author reply 580-1. PMID: 17134810 MH - Adult MH - Affect MH - Brain-Derived Neurotrophic Factor/*blood MH - Depressive Disorder, Major/*blood/*psychology MH - Enzyme-Linked Immunosorbent Assay MH - Female MH - Humans MH - Male MH - Middle Aged MH - Psychiatric Status Rating Scales MH - ROC Curve MH - Risk MH - Suicide, Attempted/*psychology EDAT- 2006/08/15 09:00 MHDA- 2007/03/16 09:00 CRDT- 2006/08/15 09:00 PHST- 2006/03/25 00:00 [received] PHST- 2006/05/27 00:00 [revised] PHST- 2006/06/30 00:00 [accepted] PHST- 2006/08/15 09:00 [pubmed] PHST- 2007/03/16 09:00 [medline] PHST- 2006/08/15 09:00 [entrez] AID - S0278-5846(06)00288-0 [pii] AID - 10.1016/j.pnpbp.2006.06.024 [doi] PST - ppublish SO - Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):78-85. doi: 10.1016/j.pnpbp.2006.06.024. Epub 2006 Aug 10.