PMID- 16904871
OWN - NLM
STAT- MEDLINE
DCOM- 20070206
LR  - 20160526
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 88
IP  - 1-3
DP  - 2006 Dec
TI  - Physical comorbidity, insight, quality of life and global functioning in first 
      episode schizophrenia: a 24-month, longitudinal outcome study.
PG  - 82-9
AB  - This prospective study sought to determine the clinical impact of physical 
      comorbidity on patients with first episode schizophrenia (FES) and we tested the 
      hypothesis that patients with physical comorbidity were associated with poorer 
      clinical and functional outcomes. The severity of psychopathology, insight, 
      social/occupational functioning and quality of life were evaluated using Positive 
      And Negative Syndrome Scale (PANSS), Scale to assess Unawareness of Mental 
      Disorder, Global Assessment of Functioning Scale (GAF), and World Health 
      Organisation Quality of Life-Bref Scale (WHOQOL-Bref) respectively at baseline 
      and at 6, 12, 18 and 24 months. Out of 142 patients, physical comorbidity was 
      present in 21.8% (n=31) of the patients, and they were mainly related to the 
      cardiovascular, respiratory and endocrine systems. Compared to baseline 
      measurements, patients with physical comorbidity had greater awareness into the 
      consequences of their psychiatric illness at 12 months, the need for treatment at 
      12 and 18 months, and better improvement of PANSS total and general 
      psychopathology subscale scores at 24 months. FES patients with physical 
      comorbidity also had less reduction in their WHOQOL-Bref scores in the physical 
      health domain at 12 and 18 months and greater increase in the GAF scores at 18 
      and 24 months, indicating better subjective rating of quality of life and 
      objective measure of their global functioning prospectively. Clinicians need to 
      be aware of the substantial rates of physical comorbidity in FES patients which 
      may not be necessarily associated with worse longitudinal outcomes and the 
      findings should encourage even greater efforts at early identification and 
      management of these physical conditions.
FAU - Sim, Kang
AU  - Sim K
AD  - Department of Adult Psychiatry, Woodbridge Hospital/ Institute of Mental Health, 
      and Biostatistics Unit, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore. kang_sim@imh.com.sg
FAU - Chan, Yiong Huak
AU  - Chan YH
FAU - Chua, Thiam Hee
AU  - Chua TH
FAU - Mahendran, Rathi
AU  - Mahendran R
FAU - Chong, Siow Ann
AU  - Chong SA
FAU - McGorry, Patrick
AU  - McGorry P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060814
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adult
MH  - Cognition Disorders/*epidemiology
MH  - Comorbidity
MH  - Demography
MH  - Female
MH  - Follow-Up Studies
MH  - *Health Status
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Quality of Life/*psychology
MH  - Schizophrenia/*epidemiology
MH  - Surveys and Questionnaires
MH  - Time Factors
EDAT- 2006/08/15 09:00
MHDA- 2007/02/07 09:00
CRDT- 2006/08/15 09:00
PHST- 2006/04/11 00:00 [received]
PHST- 2006/07/07 00:00 [revised]
PHST- 2006/07/08 00:00 [accepted]
PHST- 2006/08/15 09:00 [pubmed]
PHST- 2007/02/07 09:00 [medline]
PHST- 2006/08/15 09:00 [entrez]
AID - S0920-9964(06)00324-0 [pii]
AID - 10.1016/j.schres.2006.07.004 [doi]
PST - ppublish
SO  - Schizophr Res. 2006 Dec;88(1-3):82-9. doi: 10.1016/j.schres.2006.07.004. Epub 
      2006 Aug 14.