PMID- 16905253
OWN - NLM
STAT- MEDLINE
DCOM- 20061103
LR  - 20131121
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 406
IP  - 1-2
DP  - 2006 Oct 2
TI  - Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by 
      chronic ethanol consumption.
PG  - 76-80
AB  - The hippocampal formation has been shown to be particularly vulnerable to the 
      neurotoxic effects of chronic ethanol consumption. It was hypothesized that this 
      damage was due to the disruption of the expression of neurotrophic factors and 
      certain other proteins within the hippocampus. By using real-time reverse 
      transcription-polymerase chain reaction (RT-PCR) techniques, this study aimed to 
      determine whether chronic ethanol consumption could alter the mRNA expression 
      level of brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic 
      factor (GDNF), and oligodendrocyte myelin glycoprotein (OMgp) in the hippocampus. 
      Wistar male rats received an unrestricted access to a liquid diet containing 5% 
      (v/v) ethanol as the sole source of fluid from 10 to 29 weeks of age. Control 
      rats had unlimited access to a liquid diet containing an isocaloric amount of 
      sucrose. We found that chronic ethanol consumption did not cause significant 
      changes in the levels of mRNA for BDNF and GDNF. However, OMgp mRNA showed a 
      significant deficit in ethanol-treated animals. It is suggested that this deficit 
      may be related to the demyelination that is commonly observed in human alcoholics 
      and that this may contribute to the functional and cognitive deficits.
FAU - Okamoto, Hanayo
AU  - Okamoto H
AD  - Department of Neuropsychiatry, Faculty of Medicine, Kagawa University, 1750-1 
      Ikenobe, Miki-cho, Kagawa 761-0793, Japan.
FAU - Miki, Takanori
AU  - Miki T
FAU - Lee, Kyoung-Youl
AU  - Lee KY
FAU - Yokoyama, Toshifumi
AU  - Yokoyama T
FAU - Kuma, Hiromi
AU  - Kuma H
FAU - Wang, Zhi-Yu
AU  - Wang ZY
FAU - Gu, He
AU  - Gu H
FAU - Li, Hong-Peng
AU  - Li HP
FAU - Matsumoto, Yoshiki
AU  - Matsumoto Y
FAU - Irawan, Satriotomo
AU  - Irawan S
FAU - Bedi, Kuldip S
AU  - Bedi KS
FAU - Nakamura, Yu
AU  - Nakamura Y
FAU - Takeuchi, Yoshiki
AU  - Takeuchi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060814
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (GPI-Linked Proteins)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (MOG protein, human)
RN  - 0 (Mog protein, rat)
RN  - 0 (Myelin Proteins)
RN  - 0 (Myelin-Associated Glycoprotein)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
RN  - 0 (OMG protein, human)
RN  - 0 (Omg protein, rat)
RN  - 0 (RNA, Messenger)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcohol-Induced Disorders, Nervous System/chemically 
      induced/*metabolism/physiopathology
MH  - Animals
MH  - Atrophy/chemically induced/metabolism/physiopathology
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Central Nervous System Depressants/pharmacology
MH  - Chronic Disease
MH  - Demyelinating Diseases/*chemically induced/metabolism/physiopathology
MH  - Disease Models, Animal
MH  - Down-Regulation/drug effects/physiology
MH  - Ethanol/*pharmacology
MH  - GPI-Linked Proteins
MH  - Glial Cell Line-Derived Neurotrophic Factor/genetics
MH  - Hippocampus/*drug effects/metabolism/pathology
MH  - Male
MH  - Myelin Proteins
MH  - Myelin-Associated Glycoprotein/*genetics
MH  - Myelin-Oligodendrocyte Glycoprotein
MH  - Nerve Fibers, Myelinated/*drug effects/metabolism/pathology
MH  - Organ Size/drug effects/physiology
MH  - RNA, Messenger/drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2006/08/15 09:00
MHDA- 2006/11/04 09:00
CRDT- 2006/08/15 09:00
PHST- 2006/03/15 00:00 [received]
PHST- 2006/06/20 00:00 [revised]
PHST- 2006/07/07 00:00 [accepted]
PHST- 2006/08/15 09:00 [pubmed]
PHST- 2006/11/04 09:00 [medline]
PHST- 2006/08/15 09:00 [entrez]
AID - S0304-3940(06)00701-4 [pii]
AID - 10.1016/j.neulet.2006.07.023 [doi]
PST - ppublish
SO  - Neurosci Lett. 2006 Oct 2;406(1-2):76-80. doi: 10.1016/j.neulet.2006.07.023. Epub 
      2006 Aug 14.