PMID- 16905291
OWN - NLM
STAT- MEDLINE
DCOM- 20061107
LR  - 20131121
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 28
IP  - 4
DP  - 2006 Jul-Aug
TI  - MDMA administration to pregnant Sprague-Dawley rats results in its passage to the 
      fetal compartment.
PG  - 459-65
AB  - Recent investigations have demonstrated that prenatal 
      3,4-methylenedeoxymethamphetamine (MDMA; ecstasy) exposure in rats results in 
      significant and persistent changes in the developing brain. However, no published 
      pharmacokinetic studies exist demonstrating that MDMA administered during 
      pregnancy passes to the fetal compartment. This leaves open the question whether 
      MDMA is directly acting on the fetal brain to produce the observed changes in 
      previous studies, or whether such effects are an indirect result of MDMA 
      administration to the pregnant dam. Therefore, pregnant rats were administered a 
      single dose of MDMA (15 mg/kg, subcutaneous) at embryonic day 14 (E14) and the 
      levels of MDMA and its metabolite 3,4-methylenedioxyamphetamine (MDA) were 
      quantified in maternal plasma, amniotic fluid, and fetal brain over 8 h by HPLC. 
      The time course of MDMA and MDA metabolism was reliable and reproducible in all 
      tissues. There was a strong correlation between fetal amniotic fluid and fetal 
      brain suggesting that amniotic fluid could be used to reliably estimate fetal 
      brain levels without directly utilizing fetal brain tissue. These data also 
      provide a framework for subsequent in vitro cell culture studies using 
      biologically relevant MDMA doses.
FAU - Campbell, Nicholas G
AU  - Campbell NG
AD  - Department of Psychiatry, University of Cincinnati, 231 Albert Sabin Way ML 559, 
      Cincinnati, OH 45267, United States.
FAU - Koprich, James B
AU  - Koprich JB
FAU - Kanaan, Nicholas M
AU  - Kanaan NM
FAU - Lipton, Jack W
AU  - Lipton JW
LA  - eng
GR  - DA017399/DA/NIDA NIH HHS/United States
GR  - DA019267/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20060608
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Hallucinogens)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/pharmacokinetics
MH  - Amniotic Fluid/metabolism
MH  - Animals
MH  - Biotransformation
MH  - Brain/metabolism
MH  - Female
MH  - Fetus/*metabolism
MH  - Hallucinogens/*pharmacokinetics
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacokinetics
MH  - Pregnancy
MH  - Pregnancy, Animal/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tissue Distribution
MH  - Uterus/metabolism
EDAT- 2006/08/15 09:00
MHDA- 2006/11/09 09:00
CRDT- 2006/08/15 09:00
PHST- 2006/03/10 00:00 [received]
PHST- 2006/05/30 00:00 [revised]
PHST- 2006/05/30 00:00 [accepted]
PHST- 2006/08/15 09:00 [pubmed]
PHST- 2006/11/09 09:00 [medline]
PHST- 2006/08/15 09:00 [entrez]
AID - S0892-0362(06)00074-2 [pii]
AID - 10.1016/j.ntt.2006.05.006 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2006 Jul-Aug;28(4):459-65. doi: 10.1016/j.ntt.2006.05.006. 
      Epub 2006 Jun 8.