PMID- 16906165
OWN - NLM
STAT- MEDLINE
DCOM- 20061128
LR  - 20240209
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 7
IP  - 9
DP  - 2006 Sep
TI  - Interleukin 18-independent engagement of interleukin 18 receptor-alpha is 
      required for autoimmune inflammation.
PG  - 946-53
AB  - T helper type 1 (T(H)1) lymphocytes are considered to be the main pathogenic cell 
      type responsible for organ-specific autoimmune inflammation. As interleukin 18 
      (IL-18) is a cofactor with IL-12 in promoting T(H)1 cell development, we examined 
      the function of IL-18 and its receptor, IL-18R, in autoimmune central nervous 
      system inflammation. Similar to IL-12-deficient mice, IL-18-deficient mice were 
      susceptible to experimental autoimmune encephalomyelitis. In contrast, IL-18R 
      alpha-deficient mice were resistant to experimental autoimmune encephalomyelitis, 
      indicating involvement of an IL-18R alpha ligand other than IL-18 with 
      encephalitogenic properties. Moreover, engagement of IL-18R alpha on 
      antigen-presenting cells was required for the generation of pathogenic 
      IL-17-producing T helper cells. Thus, IL-18 and T(H)1 cells are dispensable, 
      whereas IL-18R alpha and IL-17-producing T helper cells are required, for 
      autoimmune central nervous system inflammation.
FAU - Gutcher, Ilona
AU  - Gutcher I
AD  - Neuroimmunology Unit, Neurology Clinic, University of Zurich, 8057 Zurich, 
      Switzerland.
FAU - Urich, Eduard
AU  - Urich E
FAU - Wolter, Karina
AU  - Wolter K
FAU - Prinz, Marco
AU  - Prinz M
FAU - Becher, Burkhard
AU  - Becher B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060813
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Antigens)
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-23)
RN  - 0 (Mitogens)
RN  - 0 (Receptors, Interleukin-18)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Animals
MH  - Antigen-Presenting Cells/chemistry/immunology
MH  - Antigens/immunology
MH  - Encephalomyelitis, Autoimmune, Experimental/*genetics/metabolism/pathology
MH  - Interleukin-12/metabolism
MH  - Interleukin-17/*metabolism
MH  - Interleukin-18/genetics/physiology
MH  - Interleukin-23/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Mitogens/immunology
MH  - Receptors, Interleukin-18/analysis/genetics/*physiology
MH  - Th1 Cells/*immunology
EDAT- 2006/08/15 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/08/15 09:00
PHST- 2006/03/21 00:00 [received]
PHST- 2006/07/17 00:00 [accepted]
PHST- 2006/08/15 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/08/15 09:00 [entrez]
AID - ni1377 [pii]
AID - 10.1038/ni1377 [doi]
PST - ppublish
SO  - Nat Immunol. 2006 Sep;7(9):946-53. doi: 10.1038/ni1377. Epub 2006 Aug 13.