PMID- 16909604
OWN - NLM
STAT- MEDLINE
DCOM- 20070402
LR  - 20131121
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 37
IP  - 4
DP  - 2006 Jul
TI  - [Effects of perinatal exposure to bisphenol A inducing dopaminergic neuronal cell 
      to apoptosis happening in midbrain of male rat offspring].
PG  - 570-3
AB  - OBJECTIVE: To investigate the mechanism and effect of rat perinatal exposure to 
      bisphenol A (BPA) resulting in midbrain dopaminergic neuronal cell apoptosis and 
      tyrosine hydroxylase expression of male offspring. METHODS: Rat dams were 
      randomLy divided into 4 groups on gestational day(GD) 10 and given orally the 
      bisphenol A doses as 0, 0.5, 5, 50 mg/kg x d from GD10 to weaning. The brains of 
      male offspring were obtained for detecting, with immunohistochemistry protocol, 
      the Caspase-3, Bcl-2 and tyrosine hydroxylase expression in the midbrain on 
      postnatal day 21 or 30 respectively, and the midbrain apoptotic neuronal cell 
      were detected by TUNEL on PND21. RESULTS: The expression of Caspase-3 in the 
      midbrain of rat male offspring were increased but bcl-2 were decreased on PND21 
      and 30, respectively. On PND21, apoptotic neuronal cell were found in the 
      midbrain of high and medium doses groups. TH protein expression was decreased. 
      CONCLUSION: Perinatal exposure to bisphenol A can induce the apoptosis of 
      midbrain dopaminergic neuron in the male rat offspring even after weaning, and 
      concomitantly decrease the midbrain TH immunoreactivity, this may cause the 
      abnormal function of dopaminergic pathway of rat male offspring.
FAU - Lin, Yong
AU  - Lin Y
AD  - Department of Environmental Health, School of Public Health, Fudan University, 
      Shanghai 200032, China.
FAU - Zhang, Hao
AU  - Zhang H
FAU - Wang, Wen-dong
AU  - Wang WD
FAU - Wu, De-sheng
AU  - Wu DS
FAU - Jiang, Song-hui
AU  - Jiang SH
FAU - Qu, Wei-dong
AU  - Qu WD
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Air Pollutants, Occupational)
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Estrogens, Non-Steroidal)
RN  - 0 (Phenols)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - MLT3645I99 (bisphenol A)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Air Pollutants, Occupational/toxicity
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Benzhydryl Compounds
MH  - Cells, Cultured
MH  - Dopamine/*metabolism
MH  - Estrogens, Non-Steroidal/toxicity
MH  - Female
MH  - Male
MH  - Mesencephalon/*pathology
MH  - Neurons/pathology
MH  - Phenols/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tyrosine 3-Monooxygenase/biosynthesis/genetics
EDAT- 2006/08/17 09:00
MHDA- 2007/04/03 09:00
CRDT- 2006/08/17 09:00
PHST- 2006/08/17 09:00 [pubmed]
PHST- 2007/04/03 09:00 [medline]
PHST- 2006/08/17 09:00 [entrez]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Jul;37(4):570-3.