PMID- 16910742
OWN - NLM
STAT- MEDLINE
DCOM- 20061020
LR  - 20130812
IS  - 0021-8561 (Print)
IS  - 0021-8561 (Linking)
VI  - 54
IP  - 17
DP  - 2006 Aug 23
TI  - Nonabsorbable dietary fat enhances disposal of 2,2',4,4'-tetrabromodiphenyl ether 
      in rats through interruption of enterohepatic circulation.
PG  - 6440-4
AB  - Polybrominated diphenyl ethers are lipophilic persistent organic pollutants 
      (POPs), which accumulate in the environment, leading to human exposure. The 
      compounds exert a negative impact on human health. Strategies to prevent or 
      diminish their accumulation in humans are required. We investigated in rats 
      whether the disposal rate of 14C-labeled tetrabromodiphenyl ether (BDE-47) could 
      be enhanced by increasing fecal fat excretion through dietary treatment with 
      nonabsorbable fat (sucrose polyester, SPE). As compared to control rats, SPE 
      treatment increased fecal excretion rates of fat (+188%, p < 0.05) and 14C-BDE-47 
      (+291%, p < 0.05). On the basis of biliary secretion and fecal excretion rates of 
      14C-BDE-47, SPE effectively inhibited the enterohepatic circulation of 
      14C-BDE-47. In conclusion, dietary supplementation of nonabsorbable fat can 
      enhance excretion of hydrophobic POPs by interruption of their enterohepatic 
      circulation. Our data indicate that this strategy could decrease concentrations 
      of hydrophobic POPs in the human body and thereby their impact on human health.
FAU - Meijer, Lisethe
AU  - Meijer L
AD  - Department of Pediatrics, Beatrix Children's Hospital, 9700 RB Groningen, The 
      Netherlands. Lisethe.meijer@gmail.com
FAU - Hafkamp, Anja M
AU  - Hafkamp AM
FAU - Bosman, Wouter E
AU  - Bosman WE
FAU - Havinga, Rick
AU  - Havinga R
FAU - Bergman, Ake
AU  - Bergman A
FAU - Sauer, Pieter J J
AU  - Sauer PJ
FAU - Verkade, Henkjan J
AU  - Verkade HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Carbon Radioisotopes)
RN  - 0 (Dietary Fats)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Brominated)
RN  - 0 (Phenyl Ethers)
RN  - 0 (Polybrominated Biphenyls)
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
SB  - IM
MH  - Animals
MH  - Carbon Radioisotopes
MH  - Diet
MH  - Dietary Fats/*pharmacology
MH  - Enterohepatic Circulation/*drug effects
MH  - Feces/chemistry
MH  - Halogenated Diphenyl Ethers
MH  - Hydrocarbons, Brominated/analysis/*pharmacokinetics
MH  - Intestinal Absorption
MH  - Male
MH  - Phenyl Ethers/analysis/*pharmacokinetics
MH  - Polybrominated Biphenyls
MH  - Rats
MH  - Rats, Wistar
EDAT- 2006/08/17 09:00
MHDA- 2006/10/21 09:00
CRDT- 2006/08/17 09:00
PHST- 2006/08/17 09:00 [pubmed]
PHST- 2006/10/21 09:00 [medline]
PHST- 2006/08/17 09:00 [entrez]
AID - 10.1021/jf0608827 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2006 Aug 23;54(17):6440-4. doi: 10.1021/jf0608827.