PMID- 16911358
OWN - NLM
STAT- MEDLINE
DCOM- 20070417
LR  - 20151119
IS  - 0954-7894 (Print)
IS  - 0954-7894 (Linking)
VI  - 36
IP  - 8
DP  - 2006 Aug
TI  - Total serum immunoglobulin E levels in a case-control study in asthmatic/allergic 
      patients, their family members, and healthy subjects from India.
PG  - 1019-27
AB  - BACKGROUND: Total immunoglobulin E (IgE) is an important indicator of allergic 
      disorders. However, its role in allergic patients in India has not been evaluated 
      in relation to atopic status for a reference range as compared with healthy 
      subjects. OBJECTIVE: The aim of the study was to establish serum IgE levels in a 
      diseased group, study its relationship with atopy, and to compare the same with 
      healthy volunteers in Indian subjects. METHODS: Four hundred and eighty 
      asthmatics/allergic patients, 100 first-degree relatives of asthmatics, and 120 
      unrelated normal healthy volunteers from Delhi region were recruited for the 
      study. Atopy was established by family history and skin test to common indigenous 
      allergens and, total and specific IgE measurements. Statistical analysis was 
      performed with the help of SPSS software program. RESULTS: The mean IgE levels 
      were the highest in asthmatic patients and the lowest in the control healthy 
      group. IgE was significantly high in the male than the female healthy volunteers 
      (P<0.05), but not in the diseased group. Prosopis juliflora among pollen 
      allergens and Alternaria alternata among fungal allergens were important 
      sensitizers in allergic patients with 34.7% and 17.7% skin positivity, 
      respectively. Atopic status and asthma were found to be the best predictor of 
      IgE, which was highly significant (r(2)=0.239, P<0.00001). However, at 95% 
      confidence interval as many as 50% of asthmatic patients had their IgE values in 
      the normal range. CONCLUSION: The IgE levels in Indian allergic patients is 
      significantly related to atopy, but due to wide overlap of IgE levels in patients 
      and healthy subjects, its diagnostic significance in Indian population seems to 
      be limited.
FAU - Sharma, S
AU  - Sharma S
AD  - Institute of Genomics & Integrative Biology, Delhi, India.
FAU - Kathuria, P C
AU  - Kathuria PC
FAU - Gupta, C K
AU  - Gupta CK
FAU - Nordling, K
AU  - Nordling K
FAU - Ghosh, B
AU  - Ghosh B
FAU - Singh, A B
AU  - Singh AB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 0 (Antigens, Helminth)
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Antibody Specificity
MH  - Antigens, Helminth/immunology
MH  - Ascariasis/immunology
MH  - Ascaris lumbricoides/immunology
MH  - Asthma/ethnology/*immunology/parasitology
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Hypersensitivity/ethnology/immunology/parasitology
MH  - Immunoglobulin E/*blood
MH  - Immunologic Tests
MH  - India
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Skin Tests
EDAT- 2006/08/17 09:00
MHDA- 2007/04/18 09:00
CRDT- 2006/08/17 09:00
PHST- 2006/08/17 09:00 [pubmed]
PHST- 2007/04/18 09:00 [medline]
PHST- 2006/08/17 09:00 [entrez]
AID - CEA2525 [pii]
AID - 10.1111/j.1365-2222.2006.02525.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2006 Aug;36(8):1019-27. doi: 10.1111/j.1365-2222.2006.02525.x.