PMID- 16913188
OWN - NLM
STAT- MEDLINE
DCOM- 20061201
LR  - 20171116
IS  - 0125-877X (Print)
IS  - 0125-877X (Linking)
VI  - 24
IP  - 1
DP  - 2006 Mar
TI  - Age related changes in Fas (CD95) and Fas ligand gene expression and cytokine 
      profiles in healthy Indians.
PG  - 47-56
AB  - Ageing in human and animal models show changes in many aspects of protective 
      immunity, particularly lymphopoenia and progressive decline in immune functions 
      leading to increased frequency of infection and neoplasia. However, the exact 
      mechanism of these defects is still unclear. In this study, elderly subjects 
      showed a decline in CD3+ and CD4+ T-cell subsets as well as serum IL-2 levels. 
      Serum IL-6 was significantly raised while expression of its signaling receptor 
      gp130 was significantly impaired in elderly as compared to the younger ones. 
      Additionally, all the elderly individuals showed constitutive expression of Fas 
      and FasL mRNA; however, none of the younger individuals expressed mRNA 
      transcripts constitutively although induced expression was seen in both the 
      groups. Similarly, frequency of Fas and FasL expressing CD4+ and CD8+ T-cell 
      subsets were significantly (p < 0.001) higher in elderly subjects as compared to 
      the younger ones. Elderly individuals also showed a significantly (p < 0.001) 
      higher frequency of activation induced cell death (AICD). Since interaction of 
      Fas with its cognate ligand (FasL) activates death inducing caspases leading to 
      apoptosis, and gp130 induces anti-apoptotic signal through STAT-3 pathway, these 
      results suggest that the decline in protective immune functions in aged 
      individuals may be related to Fas and FasL mediated apoptosis of peripheral 
      T-cell subsets.
FAU - Sawhney, Meenakshi
AU  - Sawhney M
AD  - Tumour and Molecular Immunology Laboratory, Department of Biotechnology, All 
      India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India.
FAU - Mathew, Mary
AU  - Mathew M
FAU - Valarmathi, Mani T
AU  - Valarmathi MT
FAU - Das, Satya N
AU  - Das SN
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Asian Pac J Allergy Immunol
JT  - Asian Pacific journal of allergy and immunology
JID - 8402034
RN  - 0 (CD3 Complex)
RN  - 0 (Cytokines)
RN  - 0 (Fas Ligand Protein)
RN  - 0 (IL6ST protein, human)
RN  - 0 (Interleukin-2)
RN  - 0 (RNA, Messenger)
RN  - 0 (fas Receptor)
RN  - 133483-10-0 (Cytokine Receptor gp130)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*immunology
MH  - Apoptosis/immunology
MH  - CD3 Complex/metabolism
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Cytokine Receptor gp130/blood
MH  - Cytokines/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fas Ligand Protein/*metabolism
MH  - Female
MH  - Flow Cytometry
MH  - Gene Expression/*immunology
MH  - Gene Expression Profiling
MH  - Humans
MH  - Immunophenotyping
MH  - India
MH  - Interleukin-2/blood
MH  - Male
MH  - Middle Aged
MH  - RNA, Messenger/analysis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - T-Lymphocyte Subsets/immunology
MH  - fas Receptor/*metabolism
EDAT- 2006/08/18 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/08/18 09:00
PHST- 2006/08/18 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/08/18 09:00 [entrez]
PST - ppublish
SO  - Asian Pac J Allergy Immunol. 2006 Mar;24(1):47-56.