PMID- 16913276
OWN - NLM
STAT- MEDLINE
DCOM- 20061020
LR  - 20190608
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 27
IP  - 3
DP  - 2006 May-Jun
TI  - Atopic dermatitis or hyper-IgE syndrome?
PG  - 289-91
AB  - A case of atopic dermatitis (AD), recurrent infections, and elevated 
      immunoglobulin E (IgE) level is presented. Clinical characteristics, 
      pathophysiology, diagnosis, and management in this patient are reviewed. Clinical 
      pearls and pitfalls include the following: (1) deep-seeded Staphylococcus aureus 
      infections occur rarely in AD and should raise the possibility of 
      immunodeficiency syndromes such as hyper-IgE syndrome (HIES); (2) HIES is 
      characterized by a clinical triad consisting of elevated serum IgE levels, 
      recurrent staphylococcal skin abscesses, and pneumonia with pneumatocele 
      formation; (3) although serum IgE levels in AD have been noted to be as high as 
      10,000 IU/mL, severe cases of AD such as that presented here can exceed this 
      range; (4) the efficacy of anti-IgE therapy in AD or HIES is unknown and may be 
      limited by dosing requirements.
FAU - Ohameje, Nkiruka U
AU  - Ohameje NU
AD  - The Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA.
FAU - Loveless, James W
AU  - Loveless JW
FAU - Saini, Sarbjit S
AU  - Saini SS
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Immunologic Factors)
RN  - 2P471X1Z11 (Omalizumab)
SB  - IM
MH  - Antibodies, Anti-Idiotypic
MH  - Antibodies, Monoclonal/therapeutic use
MH  - Antibodies, Monoclonal, Humanized
MH  - Child
MH  - Dermatitis, Atopic/*diagnosis/drug therapy
MH  - Diagnosis, Differential
MH  - Humans
MH  - Immunologic Factors/therapeutic use
MH  - Job Syndrome/*diagnosis/drug therapy
MH  - Male
MH  - Omalizumab
EDAT- 2006/08/18 09:00
MHDA- 2006/10/21 09:00
CRDT- 2006/08/18 09:00
PHST- 2006/08/18 09:00 [pubmed]
PHST- 2006/10/21 09:00 [medline]
PHST- 2006/08/18 09:00 [entrez]
AID - 10.2500/aap.2006.27.2853 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2006 May-Jun;27(3):289-91. doi: 10.2500/aap.2006.27.2853.