PMID- 1691416
OWN - NLM
STAT- MEDLINE
DCOM- 19900511
LR  - 20190724
IS  - 0160-2446 (Print)
IS  - 0160-2446 (Linking)
VI  - 15 Suppl 3
DP  - 1990
TI  - Enalapril in the treatment of congestive heart failure.
PG  - S6-10
AB  - Congestive heart failure (CHF) is a complex clinical syndrome affecting 1% of the 
      U.S. population. The basic dysfunction, a lack of sufficient blood flow to the 
      periphery, triggers reflex neurohumoral mechanisms that cause systemic 
      vasoconstriction and sodium and water retention as the body attempts to protect 
      vital organs. This, in turn, results in additional work for the failing heart and 
      further deterioration. Vasodilators, in general, and angiotensin converting 
      enzyme (ACE) inhibitors, in particular, interrupt this pathophysiology and 
      improve hemodynamics. Enalapril, a long-acting ACE inhibitor, has been 
      demonstrated to improve New York Heart Association (NYHA) functional class, 
      pulmonary capillary wedge pressure, cardiac index, maximum oxygen uptake, and 
      exercise tolerance in CHF patients. Data from a recent trial provide evidence 
      that a group of patients with severe CHF who were treated with enalapril showed 
      reduced heart size, reduced need for other heart-failure medication, and reduced 
      mortality.
FAU - Giles, T
AU  - Giles T
AD  - Department of Medicine, Tulane Medical School, New Orleans, Louisiana.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - J Cardiovasc Pharmacol
JT  - Journal of cardiovascular pharmacology
JID - 7902492
RN  - 69PN84IO1A (Enalapril)
RN  - 9G64RSX1XD (Captopril)
SB  - IM
MH  - Captopril/therapeutic use
MH  - Double-Blind Method
MH  - Enalapril/*therapeutic use
MH  - Heart Failure/*drug therapy
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Physical Exertion
MH  - Randomized Controlled Trials as Topic
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1097/00005344-199000153-00002 [doi]
PST - ppublish
SO  - J Cardiovasc Pharmacol. 1990;15 Suppl 3:S6-10. doi: 
      10.1097/00005344-199000153-00002.