PMID- 16914678
OWN - NLM
STAT- MEDLINE
DCOM- 20060912
LR  - 20221207
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 26
IP  - 33
DP  - 2006 Aug 16
TI  - Transient functional suppression and facilitation of Japanese ideogram writing 
      induced by repetitive transcranial magnetic stimulation of posterior inferior 
      temporal cortex.
PG  - 8523-30
AB  - The Japanese writing system is unique in that it is composed of two different 
      orthographies: kanji (morphograms) and kana (syllabograms). The retrieval of the 
      visual orthographic representations of Japanese kanji is crucial to the process 
      of writing in Japanese. We used low-frequency repetitive transcranial magnetic 
      stimulation (rTMS) to clarify the functional relevance of the left and right 
      posterior inferior temporal cortex (PITC) to this process in native Japanese 
      speakers. The experimental paradigms included the mental recall of kanji, 
      kana-to-kanji transcription, semantic judgment, oral reading, and copying of kana 
      and kanji. The first two tasks require the visualization of the kanji image of 
      the word. We applied 0.9 Hz rTMS (600 total pulses) over individually determined 
      left or right PITC to suppress cortical activity and measured subsequent task 
      performance. In the mental recall of kanji and kana-to-kanji transcription, rTMS 
      over the left PITC prolonged reaction times (RTs), whereas rTMS over the right 
      PITC reduced RTs. In the other tasks, which do not involve the mental 
      visualization of kanji, rTMS over the left or right PITC had no effect on 
      performance. These results suggest that the left PITC is crucial for the 
      retrieval of the visual graphic representation of kanji. Furthermore, the right 
      PITC may work to suppress the dominant left PITC in the neural network for kanji 
      writing, which involves visual word recognition.
FAU - Ueki, Yoshino
AU  - Ueki Y
AD  - Human Brain Research Center, Kyoto University Graduate School of Medicine, 
      Sakyo-ku, Kyoto 606-8507, Japan.
FAU - Mima, Tatsuya
AU  - Mima T
FAU - Nakamura, Kimihiro
AU  - Nakamura K
FAU - Oga, Tatsuhide
AU  - Oga T
FAU - Shibasaki, Hiroshi
AU  - Shibasaki H
FAU - Nagamine, Takashi
AU  - Nagamine T
FAU - Fukuyama, Hidenao
AU  - Fukuyama H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Adult
MH  - *Asian People
MH  - Female
MH  - *Handwriting
MH  - Humans
MH  - *Language
MH  - Male
MH  - Temporal Lobe/*physiology
MH  - *Transcranial Magnetic Stimulation
PMC - PMC6674341
EDAT- 2006/08/18 09:00
MHDA- 2006/09/13 09:00
PMCR- 2007/02/16
CRDT- 2006/08/18 09:00
PHST- 2006/08/18 09:00 [pubmed]
PHST- 2006/09/13 09:00 [medline]
PHST- 2006/08/18 09:00 [entrez]
PHST- 2007/02/16 00:00 [pmc-release]
AID - 26/33/8523 [pii]
AID - 10.1523/JNEUROSCI.0846-06.2006 [doi]
PST - ppublish
SO  - J Neurosci. 2006 Aug 16;26(33):8523-30. doi: 10.1523/JNEUROSCI.0846-06.2006.