PMID- 16915538
OWN - NLM
STAT- MEDLINE
DCOM- 20060928
LR  - 20161124
IS  - 0947-7349 (Print)
IS  - 0947-7349 (Linking)
VI  - 114
IP  - 7
DP  - 2006 Jul
TI  - Small neuroendocrine pancreatic tumors in multiple endocrine neoplasia type 1 
      (MEN1): least significant change of tumor diameter as determined by endoscopic 
      ultrasound (EUS) imaging.
PG  - 361-5
AB  - Endosonography enables detection and localization of small pancreatic 
      neuroendocrine tumors (PETs) which cannot be detected by computed tomography, 
      magnetic resonance imaging, or somatostatin receptor scintigraphy. Knowledge 
      about the prognosis of very small PETs in MEN1 is limited, and if there are no 
      clinical symptoms, endocrine activity or mechanical problems and thus no clear 
      indication for surgical therapy, an appropriate decision for the management of 
      such patients might be to control their follow-up by endosonographic imaging. 
      Therefore, the reproducibility of the measurement of the diameter of very small 
      PETs by endosonographic imaging was investigated in this prospective study. We 
      included 33 PETs smaller than 15 mm in their largest diameter detected by 
      endosonographic imaging (Pentax FG 32 UA) in ten patients with genetically 
      confirmed MEN1-disease. Three repeated measurements of each tumor were performed. 
      Reproducibility was expressed as mean coefficient of variation of intra-observer 
      variability. Mean tumor diameter was 6.9 +/- 3.4 mm (range 2.8 - 14.2 mm). Mean 
      coefficient of variation was 5.5 +/- 4.6 % (range 0.0 - 19.4 %): in tumors < 5 mm 
      (n = 13) 7.1 +/- 6.3 %, in tumors > 5 mm (n = 20) 4.4 +/- 2.6 %. Least 
      significant change (p < 0.05) was calculated as 15.4 % (tumors < 5 mm: 19.9 %; 
      tumors > 5 mm: 12.3 %). In conclusion, endosonographic imaging enables the 
      measurement of small PETs with an acceptable reproducibility. Changes of tumor 
      diameter of more than 20 % have to be taken as statistically significant.
FAU - Kann, P H
AU  - Kann PH
AD  - Endocrinology & Diabetology, Philipp's University Medical School, Marburg, 
      Germany. Kannp@med.uni-marburg.de
FAU - Kann, B
AU  - Kann B
FAU - Fassbender, W J
AU  - Fassbender WJ
FAU - Forst, T
AU  - Forst T
FAU - Bartsch, D K
AU  - Bartsch DK
FAU - Langer, P
AU  - Langer P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Exp Clin Endocrinol Diabetes
JT  - Experimental and clinical endocrinology & diabetes : official journal, German 
      Society of Endocrinology [and] German Diabetes Association
JID - 9505926
SB  - IM
MH  - Carcinoma, Neuroendocrine/*diagnostic imaging/pathology
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*diagnostic imaging
MH  - Pancreatic Neoplasms/*diagnostic imaging/pathology
MH  - Positron-Emission Tomography
MH  - Prospective Studies
MH  - Radiography
MH  - Reproducibility of Results
MH  - Ultrasonography
EDAT- 2006/08/18 09:00
MHDA- 2006/09/29 09:00
CRDT- 2006/08/18 09:00
PHST- 2006/08/18 09:00 [pubmed]
PHST- 2006/09/29 09:00 [medline]
PHST- 2006/08/18 09:00 [entrez]
AID - 10.1055/s-2006-924322 [doi]
PST - ppublish
SO  - Exp Clin Endocrinol Diabetes. 2006 Jul;114(7):361-5. doi: 10.1055/s-2006-924322.