PMID- 16916354
OWN - NLM
STAT- MEDLINE
DCOM- 20070525
LR  - 20220331
IS  - 1467-2987 (Print)
IS  - 1467-2987 (Linking)
VI  - 33
IP  - 5
DP  - 2006 Sep
TI  - A comparison between pre-operative carprofen and a long-acting sufentanil 
      formulation for analgesia after ovariohysterectomy in dogs.
PG  - 313-27
AB  - OBJECTIVE: To assess the analgesic efficacy and adverse effects of a novel, 
      long-acting sufentanil preparation in dogs undergoing ovariohysterectomy (OHE). 
      STUDY DESIGN: Blinded, positively controlled, randomized field trial with four 
      parallel treatment groups. ANIMALS: Eighty client owned dogs undergoing elective 
      OHE randomly allocated into four treatment groups (each n = 20). MATERIALS AND 
      METHODS: Three groups received intramuscular (IM) sufentanil (at 10, 15 and 25 
      microg kg(-1), respectively) and the control group received subcutaneous (SC) 
      carprofen 4 mg kg(-1) SC plus acepromazine 0.05 mg kg(-1) IM as pre-anaesthetic 
      medication. OHE was performed under thiopental/halothane anaesthesia. Visual 
      Analogue Scale (VAS) scores for pain and sedation were awarded and mechanical 
      nociceptive thresholds were measured at the wound and hock before surgery and up 
      to 24 hours after tracheal extubation. Serum cortisol was measured before 
      surgery, during surgery and up to 24 hours after tracheal extubation. Animals 
      with inadequate post-operative analgesia were given rescue medication. RESULTS: 
      In the carprofen group, VAS pain scores were significantly higher, wound 
      tenderness was greater and requirement for rescue analgesia was more than in the 
      sufentanil-treated groups. Sufentanil produced dose dependent analgesia and 
      sedation. All treatment groups showed similar patterns of change for cortisol 
      concentrations. Use of the sufentanil preparation was associated with a 
      relatively high incidence of adverse events. CONCLUSIONS: The long-acting 
      preparation of sufentanil provided excellent post-operative analgesia that was 
      significantly better than that provided by carprofen. However, use of this 
      formulation, in the anaesthetic technique used in the study, resulted in a 
      relatively high incidence of adverse effects. CLINICAL RELEVANCE: Full mu (MOP) 
      opioid agonists provide significantly better post-operative analgesia than 
      nonsteroidal anti-inflammatory drugs after moderately painful surgery. However, 
      the widely recognized adverse effects of opioids may preclude the use of these 
      agents.
FAU - Slingsby, Louisa S
AU  - Slingsby LS
AD  - Division of Companion Animals, Department of Clinical Veterinary Science, 
      University of Bristol, Bristol, UK. louisa.slingsby@bristol.ac.uk
FAU - Murison, Pamela J
AU  - Murison PJ
FAU - Goossens, Lieve
AU  - Goossens L
FAU - Engelen, Marc
AU  - Engelen M
FAU - Waterman-Pearson, Avril E
AU  - Waterman-Pearson AE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Vet Anaesth Analg
JT  - Veterinary anaesthesia and analgesia
JID - 100956422
RN  - 0 (Analgesics)
RN  - 0 (Carbazoles)
RN  - 0 (Delayed-Action Preparations)
RN  - AFE2YW0IIZ (Sufentanil)
RN  - FFL0D546HO (carprofen)
SB  - IM
MH  - Analgesia/*veterinary
MH  - Analgesics/administration & dosage/therapeutic use
MH  - Animals
MH  - Carbazoles/administration & dosage/*therapeutic use
MH  - Delayed-Action Preparations
MH  - Dogs/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Hysterectomy/adverse effects/*veterinary
MH  - Ovariectomy/adverse effects/*veterinary
MH  - Pain, Postoperative/*drug therapy
MH  - Sufentanil/administration & dosage/*therapeutic use
MH  - Time Factors
EDAT- 2006/08/19 09:00
MHDA- 2007/05/26 09:00
CRDT- 2006/08/19 09:00
PHST- 2006/08/19 09:00 [pubmed]
PHST- 2007/05/26 09:00 [medline]
PHST- 2006/08/19 09:00 [entrez]
AID - S1467-2987(16)30882-0 [pii]
AID - 10.1111/j.1467-2995.2005.00267.x [doi]
PST - ppublish
SO  - Vet Anaesth Analg. 2006 Sep;33(5):313-27. doi: 10.1111/j.1467-2995.2005.00267.x.