PMID- 16916657
OWN - NLM
STAT- MEDLINE
DCOM- 20061222
LR  - 20060818
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 8
DP  - 2006 Aug
TI  - Adulthood-onset celiac disease is associated with intercellular adhesion 
      molecule-1 (ICAM-1) gene polymorphism.
PG  - 612-7
AB  - Celiac disease (CD) is a multifactorial T-cell-mediated autoimmune disease 
      characterized by gluten-triggered villous atrophy and malabsorption. Although 
      human leukocyte antigen (HLA) class II genes are strong susceptibility factors, 
      non-HLA genes likely contribute to most of CD predisposition. The intercellular 
      adhesion molecule-1 (ICAM-1) gene is a good candidate for CD predisposition 
      because its encoded protein acts as an adhesion and costimulatory receptor. Two 
      single-base polymorphisms (G/A in exon 4 encoding G241R, and A/G in exon 6 
      encoding K469E) were analyzed in 180 French Caucasian CD case patients (110 
      patients diagnosed before the age of 15 and 70 patients after the age of 18), and 
      212 French Caucasian healthy controls. The R241 allele frequency was increased in 
      CD case patients compared with controls (14.2% vs. 5.4% respectively, p = 
      0.000015, odds ratio [OR] for the R241 allele = 2.9, 95% confidence intervals 
      [CI] = 1.7-4.8). After stratifying for age of disease onset, the R241 variant 
      mainly conferred predisposition to CD occurring during adulthood (OR = 4.2, 95% 
      CI = 2.3-7.5, Pc = 0.000004 for adulthood-onset CD vs. R = 2.1, 95%, CI = 
      1.2-3.9, Pc = 0.0047 for childhood-onset CD). Position 241 of ICAM-1 maps to the 
      binding site for the integrin Mac-1 and might modify the strength of interaction 
      between endothelium and immune cells. If confirmed in independent datasets, these 
      results may be of importance in at-risk individuals to distinguish rapid from 
      delayed progression to clinical CD.
FAU - Abel, Michal
AU  - Abel M
AD  - INSERM U561 Equipe AVENIR, Hopital St-Vincent de Paul, Paris, France.
FAU - Cellier, Christophe
AU  - Cellier C
FAU - Kumar, Neeraj
AU  - Kumar N
FAU - Cerf-Bensussan, Nadine
AU  - Cerf-Bensussan N
FAU - Schmitz, Jacques
AU  - Schmitz J
FAU - Caillat-Zucman, Sophie
AU  - Caillat-Zucman S
LA  - eng
PT  - Journal Article
DEP - 20060524
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Celiac Disease/epidemiology/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/*genetics
MH  - *Polymorphism, Single Nucleotide
EDAT- 2006/08/19 09:00
MHDA- 2006/12/23 09:00
CRDT- 2006/08/19 09:00
PHST- 2006/02/03 00:00 [received]
PHST- 2006/08/19 09:00 [pubmed]
PHST- 2006/12/23 09:00 [medline]
PHST- 2006/08/19 09:00 [entrez]
AID - S0198-8859(06)00110-8 [pii]
AID - 10.1016/j.humimm.2006.04.011 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Aug;67(8):612-7. doi: 10.1016/j.humimm.2006.04.011. Epub 2006 
      May 24.