PMID- 16916662
OWN - NLM
STAT- MEDLINE
DCOM- 20061222
LR  - 20220410
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 67
IP  - 8
DP  - 2006 Aug
TI  - Association of HLA-DR, -DQ, and vitamin D receptor alleles and haplotypes with 
      tuberculosis in the Venda of South Africa.
PG  - 643-54
AB  - The vitamin D receptor (VDR) and the human leukocyte antigen (HLA) class II 
      complex affect innate and/or adaptive immunity against Mycobacterium 
      tuberculosis. HLA-DRB1, HLA-DQB1, and VDR gene (VDR) polymorphisms were 
      previously associated with tuberculosis (TB) and are here investigated as 
      candidates for TB susceptibility in the Venda population of South Africa. Genomic 
      DNA from 95 patients with pulmonary tuberculosis (PTB) and 117 ethnically 
      matched, healthy controls were typed for HLA-DRB1, DRB3, DRB4, DRB5, DQB1, and 
      VDR polymorphisms FokI, BsmI, ApaI, and TaqI using polymerase chain 
      reaction-sequence specific primers (PCR-SSP). Allele and haplotype frequencies 
      were calculated by the estimator maximum (EM) algorithm. DRB1*1302 phenotype was 
      significantly associated with TB occurring at a significantly higher allele 
      frequency in cases than controls and found in haplotype with DQB1*0602/3. 
      DQB1*0301-0304 phenotype was significantly associated with TB and found in 
      haplotype with DRB1*1101-1121, showing significant linkage disequilibrium (LD) in 
      both cases and controls. Only DRB1*1101-1121-DQB1*05 was significantly associated 
      with TB based on the sequential Bonferroni p value. VDR SNP phenotypes were not 
      associated with TB, but the haplotype F-b-A-T significantly protected from TB. In 
      conclusion, common African HLA-DRB1 and -DQB1 variants, previously associated 
      with protection from malaria and hepatitis B/C virus persistence, predispose the 
      Venda to TB, whereas the proposedly active VDR haplotype F-b-A-T showed 
      significant protection.
FAU - Lombard, Zane
AU  - Lombard Z
AD  - Department of Biochemistry, University of Johannesburg, Auckland Park, South 
      Africa.
FAU - Dalton, Desire-Lee
AU  - Dalton DL
FAU - Venter, Philip A
AU  - Venter PA
FAU - Williams, Robert C
AU  - Williams RC
FAU - Bornman, Liza
AU  - Bornman L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060522
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Receptors, Calcitriol)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, Calcitriol/*genetics
MH  - South Africa
MH  - Tuberculosis, Pulmonary/*genetics
EDAT- 2006/08/19 09:00
MHDA- 2006/12/23 09:00
CRDT- 2006/08/19 09:00
PHST- 2005/02/11 00:00 [received]
PHST- 2006/08/19 09:00 [pubmed]
PHST- 2006/12/23 09:00 [medline]
PHST- 2006/08/19 09:00 [entrez]
AID - S0198-8859(06)00107-8 [pii]
AID - 10.1016/j.humimm.2006.04.008 [doi]
PST - ppublish
SO  - Hum Immunol. 2006 Aug;67(8):643-54. doi: 10.1016/j.humimm.2006.04.008. Epub 2006 
      May 22.