PMID- 16916910
OWN - NLM
STAT- MEDLINE
DCOM- 20070305
LR  - 20220227
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 576
IP  - Pt 3
DP  - 2006 Nov 1
TI  - Down-regulation of placental transport of amino acids precedes the development of 
      intrauterine growth restriction in rats fed a low protein diet.
PG  - 935-46
AB  - Intrauterine growth restriction (IUGR) represents an important risk factor for 
      perinatal complications and for adult disease. IUGR is associated with a 
      down-regulation of placental amino acid transporters; however, whether these 
      changes are primary events directly contributing to IUGR or a secondary 
      consequence is unknown. We investigated the time course of changes in placental 
      and fetal growth, placental nutrient transport in vivo and the expression of 
      placental nutrient transporters in pregnant rats subjected to protein 
      malnutrition, a model for IUGR. Pregnant rats were given either a low protein 
      (LP) diet (n = 64) or an isocaloric control diet (n = 66) throughout pregnancy. 
      Maternal insulin, leptin and IGF-I levels decreased, whereas maternal amino acid 
      concentrations increased moderately in response to the LP diet. Fetal and 
      placental weights in the LP group were unaltered compared to control diet at 
      gestational day (GD) 15, 18 and 19 but significantly reduced at GD 21. Placental 
      system A transport activity was reduced at GD 19 and 21 in response to a low 
      protein diet. Placental protein expression of SNAT2 was decreased at GD 21. In 
      conclusion, placental amino acid transport is down-regulated prior to the 
      development of IUGR, suggesting that these placental transport changes are a 
      cause, rather than a consequence, of IUGR. Reduced maternal levels of insulin, 
      leptin and IGF-1 may link maternal protein malnutrition to reduced fetal growth 
      by down-regulation of key placental amino acid transporters.
FAU - Jansson, Nina
AU  - Jansson N
AD  - Perinatal Center, Institute of Neuroscience and Physiology, Goteborg University, 
      Sweden. nina.jansson@fysiologi.gu.se
FAU - Pettersson, Jessica
AU  - Pettersson J
FAU - Haafiz, Allah
AU  - Haafiz A
FAU - Ericsson, Anette
AU  - Ericsson A
FAU - Palmberg, Isabelle
AU  - Palmberg I
FAU - Tranberg, Mattias
AU  - Tranberg M
FAU - Ganapathy, Vadivel
AU  - Ganapathy V
FAU - Powell, Theresa L
AU  - Powell TL
FAU - Jansson, Thomas
AU  - Jansson T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
RN  - 0 (Amino Acid Transport System A)
RN  - 0 (Amino Acid Transport Systems)
RN  - 0 (Amino Acids)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
RN  - 0 (Slc38a2 protein, rat)
RN  - 11P2JDE17B (beta-Alanine)
RN  - 19036-43-2 (2,2-dimethyl-beta-alanine)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
CIN - J Physiol. 2006 Nov 1;576(Pt 3):649. PMID: 16973694
MH  - Amino Acid Transport System A
MH  - Amino Acid Transport Systems/genetics/metabolism
MH  - Amino Acids/genetics/*metabolism
MH  - Animals
MH  - Biological Transport/genetics/physiology
MH  - *Diet, Protein-Restricted
MH  - Down-Regulation/physiology
MH  - Female
MH  - Fetal Growth Retardation/*metabolism/*physiopathology
MH  - Gene Expression Regulation/physiology
MH  - Glucose/metabolism
MH  - Insulin/blood
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Leptin/blood
MH  - Placenta/*metabolism/physiopathology
MH  - Pregnancy
MH  - Protein Kinases/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/genetics/physiology
MH  - TOR Serine-Threonine Kinases
MH  - beta-Alanine/analogs & derivatives/metabolism
PMC - PMC1892642
EDAT- 2006/08/19 09:00
MHDA- 2007/03/06 09:00
PMCR- 2007/11/01
CRDT- 2006/08/19 09:00
PHST- 2006/08/19 09:00 [pubmed]
PHST- 2007/03/06 09:00 [medline]
PHST- 2006/08/19 09:00 [entrez]
PHST- 2007/11/01 00:00 [pmc-release]
AID - jphysiol.2006.116509 [pii]
AID - 10.1113/jphysiol.2006.116509 [doi]
PST - ppublish
SO  - J Physiol. 2006 Nov 1;576(Pt 3):935-46. doi: 10.1113/jphysiol.2006.116509.