PMID- 16918514
OWN - NLM
STAT- MEDLINE
DCOM- 20070110
LR  - 20090626
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 61
IP  - 9
DP  - 2006 Sep
TI  - European birth cohort studies on asthma and atopic diseases: II. Comparison of 
      outcomes and exposures--a GA2LEN initiative.
PG  - 1104-11
AB  - BACKGROUND: The Global Allergy and Asthma European Network (GA2LEN) is a 
      consortium of 26 leading European research centres committed to establish a 
      European research area of excellence in the field of allergy and asthma. AIM: One 
      of the GA2LEN work packages was designed to identify and compare the existing 
      European birth cohort studies on asthma and atopic diseases. The present review 
      compares their subjective and objective outcomes as well as exposure variables. 
      METHODS: A common database was established to assess study characteristics of 
      observational birth cohort studies designed to examine asthma and atopic 
      diseases. Data were collected by visiting most of the participating research 
      teams and interviewing all relevant study personnel. For each study, the type of 
      objective/subjective outcome parameters and potentially influential factors were 
      recorded precisely for every time point during follow-up. RESULTS: Eighteen birth 
      cohort studies on asthma and atopic diseases were identified in eight European 
      countries. Thirteen studies collected data on specific immunoglobulin E (IgE) to 
      various inhalant and food allergens, whereas 12 performed skin prick tests (many 
      at several time points during follow up). Several studies measured lung function, 
      but across the cohorts no comparable standard procedures were used. For 
      subjective evaluation of asthma and allergic rhinitis most studies applied the 
      ISAAC questionnaire (sometimes modified), whereas the assessment of eczema was 
      rather heterogeneous across the studies. CONCLUSION: This GA2LEN initiative 
      established a unique common database of 18 European birth cohorts on asthma and 
      atopic diseases. For selected cohorts, it seems that pooling data and performing 
      common analyses may be possible to examine associations between certain exposure 
      variables (e.g. pet ownership, tobacco smoke exposure and day-care) and selected 
      outcome measures for atopy, asthma or allergic rhinitis (e.g. sensitization 
      assessed by IgE or skin prick tests, doctor's diagnosis of asthma, parental 
      perception regarding asthma/wheezing or hay fever symptoms).
FAU - Keil, T
AU  - Keil T
AD  - Institute for Social Medicine, Epidemiology and Health Economics, Charite, 
      Berlin, Germany.
FAU - Kulig, M
AU  - Kulig M
FAU - Simpson, A
AU  - Simpson A
FAU - Custovic, A
AU  - Custovic A
FAU - Wickman, M
AU  - Wickman M
FAU - Kull, I
AU  - Kull I
FAU - Lodrup Carlsen, K C
AU  - Lodrup Carlsen KC
FAU - Carlsen, K H
AU  - Carlsen KH
FAU - Smit, H A
AU  - Smit HA
FAU - Wijga, A H
AU  - Wijga AH
FAU - Schmid, S
AU  - Schmid S
FAU - Von Berg, A
AU  - Von Berg A
FAU - Bollrath, C
AU  - Bollrath C
FAU - Eller, E
AU  - Eller E
FAU - Bindslev-Jensen, C
AU  - Bindslev-Jensen C
FAU - Halken, S
AU  - Halken S
FAU - Host, A
AU  - Host A
FAU - Heinrich, J
AU  - Heinrich J
FAU - Fantini, M P
AU  - Fantini MP
FAU - Brunekreef, B
AU  - Brunekreef B
FAU - Kramer, U
AU  - Kramer U
FAU - Willich, S N
AU  - Willich SN
FAU - Wahn, U
AU  - Wahn U
FAU - Lau, S
AU  - Lau S
CN  - working group of GA2LEN-WP 1.5 Birth Cohorts
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/epidemiology/immunology/physiopathology/*therapy
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Environmental Exposure/adverse effects
MH  - Europe
MH  - Humans
MH  - Hypersensitivity, Immediate/epidemiology/immunology/physiopathology/*therapy
MH  - Immunoglobulin E/blood
MH  - Respiratory Function Tests
MH  - Skin Tests
MH  - Treatment Outcome
EDAT- 2006/08/22 09:00
MHDA- 2007/01/11 09:00
CRDT- 2006/08/22 09:00
PHST- 2006/08/22 09:00 [pubmed]
PHST- 2007/01/11 09:00 [medline]
PHST- 2006/08/22 09:00 [entrez]
AID - ALL1167 [pii]
AID - 10.1111/j.1398-9995.2006.01167.x [doi]
PST - ppublish
SO  - Allergy. 2006 Sep;61(9):1104-11. doi: 10.1111/j.1398-9995.2006.01167.x.