PMID- 16918612
OWN - NLM
STAT- MEDLINE
DCOM- 20061207
LR  - 20201209
IS  - 0105-1873 (Print)
IS  - 0105-1873 (Linking)
VI  - 55
IP  - 3
DP  - 2006 Sep
TI  - Skin sensitization potency of methyl methacrylate in the local lymph node assay: 
      comparisons with guinea-pig data and human experience.
PG  - 140-7
AB  - There is compelling evidence that contact allergens differ substantially (by 4 or 
      5 orders of magnitude) with respect to their inherent skin-sensitizing potency. 
      Relative potency can now be measured effectively using the mouse local lymph node 
      assay (LLNA) and such data form the basis of risk assessment and risk management 
      strategies. Such determinations also facilitate distinctions being drawn between 
      the prevalence of skin sensitization to a particular contact allergen and 
      inherent potency. The distinction is important because chemicals that are 
      implicated as common causes of contact allergy are not necessarily potent 
      sensitizers. One example is provided by nickel that is undoubtedly a common cause 
      of allergic contact dermatitis, but is a comparatively weak sensitizer in 
      predictive tests. In an attempt to explore other examples of contact allergens 
      where there may exist a discrepancy between prevalence and potency, we describe 
      here analyses conducted with methyl methacrylate (MMA). Results of LLNA studies 
      have been interpreted in the context of historical clinical data on occupational 
      allergic contact dermatitis associated with exposure to MMA.
FAU - Betts, Catherine J
AU  - Betts CJ
AD  - Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK1 
      4TJ, UK. catherine.betts@syngenta.com
FAU - Dearman, Rebecca J
AU  - Dearman RJ
FAU - Heylings, Jon R
AU  - Heylings JR
FAU - Kimber, Ian
AU  - Kimber I
FAU - Basketter, David A
AU  - Basketter DA
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Contact Dermatitis
JT  - Contact dermatitis
JID - 7604950
RN  - 0 (Allergens)
RN  - 0 (Dinitrochlorobenzene)
RN  - 196OC77688 (Methylmethacrylate)
SB  - IM
MH  - Allergens/*toxicity
MH  - Animals
MH  - Dermatitis, Allergic Contact/*diagnosis/pathology
MH  - Dinitrochlorobenzene/toxicity
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Guinea Pigs
MH  - Humans
MH  - *Local Lymph Node Assay
MH  - Lymph Nodes/drug effects
MH  - Methylmethacrylate/*toxicity
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Predictive Value of Tests
MH  - Skin/*drug effects
MH  - Skin Absorption/drug effects
MH  - Skin Tests/*methods
EDAT- 2006/08/22 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/08/22 09:00
PHST- 2006/08/22 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/08/22 09:00 [entrez]
AID - COD898 [pii]
AID - 10.1111/j.1600-0536.2006.00898.x [doi]
PST - ppublish
SO  - Contact Dermatitis. 2006 Sep;55(3):140-7. doi: 10.1111/j.1600-0536.2006.00898.x.