PMID- 16918923
OWN - NLM
STAT- MEDLINE
DCOM- 20060928
LR  - 20071114
IS  - 0006-341X (Print)
IS  - 0006-341X (Linking)
VI  - 62
IP  - 2
DP  - 2006 Jun
TI  - Nonparametric statistical methods for cost-effectiveness analyses.
PG  - 576-88
AB  - Two measures often used in a cost-effectiveness analysis are the incremental 
      cost-effectiveness ratio (ICER) and the net health benefit (NHB). Inferences on 
      these two quantities are often hindered by highly skewed cost data. In this 
      article, we derive the Edgeworth expansions for the studentized t-statistics for 
      the two measures and show how they could be used to guide inferences. In 
      particular, we use the expansions to study the theoretical performance of 
      existing confidence intervals based on normal theory and to derive new confidence 
      intervals for the ICER and the NHB. We conduct a simulation study to compare our 
      new intervals with several existing methods. The methods evaluated include 
      Taylor's interval, Fieller's interval, the bootstrap percentile interval, and the 
      bootstrap bias-corrected acceleration interval. We found that our new intervals 
      give good coverage accuracy and are narrower compared to the current recommended 
      intervals.
FAU - Dinh, Phillip
AU  - Dinh P
AD  - Department of Biostatistics, University of Washington, Box 357232, Seattle, 
      Washington 98195, USA.
FAU - Zhou, Xiao-Hua
AU  - Zhou XH
LA  - eng
GR  - R01HS013105/HS/AHRQ HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - England
TA  - Biometrics
JT  - Biometrics
JID - 0370625
SB  - IM
MH  - Biometry
MH  - Confidence Intervals
MH  - Cost-Benefit Analysis/*statistics & numerical data
MH  - Data Interpretation, Statistical
MH  - Health Services Research
MH  - Humans
MH  - Models, Statistical
MH  - *Statistics, Nonparametric
EDAT- 2006/08/22 09:00
MHDA- 2006/09/29 09:00
CRDT- 2006/08/22 09:00
PHST- 2006/08/22 09:00 [pubmed]
PHST- 2006/09/29 09:00 [medline]
PHST- 2006/08/22 09:00 [entrez]
AID - BIOM509 [pii]
AID - 10.1111/j.1541-0420.2006.00509.x [doi]
PST - ppublish
SO  - Biometrics. 2006 Jun;62(2):576-88. doi: 10.1111/j.1541-0420.2006.00509.x.