PMID- 16919594
OWN - NLM
STAT- MEDLINE
DCOM- 20071012
LR  - 20061113
IS  - 0003-9969 (Print)
IS  - 0003-9969 (Linking)
VI  - 51
IP  - 12
DP  - 2006 Dec
TI  - Deterioration of the Langerhans cell network of the human gingival epithelium 
      with aging.
PG  - 1150-5
AB  - Dendritic cells (DCs) are the professional antigen-presenting cells responsible 
      for initiating of the immune response. Langerhans cells (LCs) are a type of DC 
      that is a permanent resident of the oral epithelium. LCs are organized conforming 
      a network in such a way as to maximize their surface area for efficient 
      apprehension of antigens. To detect age-related changes in the LCs network, 
      fragments of gingival epithelium spontaneously accompanying dental removals were 
      processed by immunohistochemistry. Monoclonal antibody CD1a followed by 
      biotinized immunoglobulin-streptoavidin peroxidase were used to identify the LCs 
      with the light microscope. LC density and LC types were analyzed according to 
      their morphology and intraepithelial distribution. In the older age group (61-74 
      years) the density was significantly lower than in the younger age groups. 
      Morphologically, LCs showed fewer dendritic-branching processes and had a rounded 
      shape in the older age group. Present observations indicate that the LC network 
      changes markedly with aging. These results suggest that immunological defense of 
      the oral tissue might be compromised in old age.
FAU - Zavala, Walther David
AU  - Zavala WD
AD  - Instituto de Histologia y Embriologia y Facultad de Odontologia, Universidad 
      Nacional de Cuyo, Casilla de Correo 56, Mendoza, Argentina. 
      waltherzavala@hotmail.com
FAU - Cavicchia, Juan Carlos
AU  - Cavicchia JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060821
PL  - England
TA  - Arch Oral Biol
JT  - Archives of oral biology
JID - 0116711
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aging/*physiology
MH  - Cell Count
MH  - Epithelium
MH  - Gingiva/*cytology
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - Langerhans Cells/*cytology
MH  - Middle Aged
MH  - Mouth Mucosa/cytology
EDAT- 2006/08/22 09:00
MHDA- 2007/10/13 09:00
CRDT- 2006/08/22 09:00
PHST- 2006/01/03 00:00 [received]
PHST- 2006/06/01 00:00 [revised]
PHST- 2006/06/12 00:00 [accepted]
PHST- 2006/08/22 09:00 [pubmed]
PHST- 2007/10/13 09:00 [medline]
PHST- 2006/08/22 09:00 [entrez]
AID - S0003-9969(06)00153-1 [pii]
AID - 10.1016/j.archoralbio.2006.06.008 [doi]
PST - ppublish
SO  - Arch Oral Biol. 2006 Dec;51(12):1150-5. doi: 10.1016/j.archoralbio.2006.06.008. 
      Epub 2006 Aug 21.