PMID- 1692004
OWN - NLM
STAT- MEDLINE
DCOM- 19900604
LR  - 20190819
IS  - 0309-0167 (Print)
IS  - 0309-0167 (Linking)
VI  - 16
IP  - 3
DP  - 1990 Mar
TI  - Subepithelial basement membrane deposition and intermediate filament expression 
      in choroid plexus neoplasms and ependymomas.
PG  - 251-5
AB  - The pattern of basement membrane deposition was investigated in benign and 
      malignant choroid plexus tumours using an immunocytochemical method to detect 
      laminin, an intrinsic basement membrane component. The results were compared with 
      intracranial ependymomas and myxopapillary ependymomas of the filum terminale. 
      Expression of the intermediate filaments cytokeratin and glial fibrillar acidic 
      protein (GFAP) and the epithelial marker carcino-embroyonic antigen (CEA) was 
      also assessed. Laminin was detected in a subepithelial location in all the 
      choroid plexus tumours but in none of the ependymomas, although basement membrane 
      fragmentation was seen in the choroid plexus carcinomas. In contrast, GFAP was 
      present in all the types of tumour examined. Cytokeratin (as detected by CAM 5.2) 
      was present in all the choroid plexus lesions and also in the ependymomas arising 
      in the spinal canal. CEA was not detected. We conclude that immunostaining for 
      laminin assists distinction between choroid plexus tumors and papillary 
      ependymomas and between benign and malignant choroid plexus tumours.
FAU - Furness, P N
AU  - Furness PN
AD  - Department of Histopathology, University Hospital, Nottingham, UK.
FAU - Lowe, J
AU  - Lowe J
FAU - Tarrant, G S
AU  - Tarrant GS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Intermediate Filament Proteins)
RN  - 0 (Laminin)
RN  - 68238-35-7 (Keratins)
SB  - IM
MH  - Basement Membrane/*pathology
MH  - Cerebral Ventricle Neoplasms/*metabolism/pathology
MH  - Choroid Plexus/*metabolism/pathology
MH  - Ependymoma/*metabolism/pathology
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Intermediate Filament Proteins/*metabolism
MH  - Keratins/metabolism
MH  - Laminin/metabolism
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
AID - 10.1111/j.1365-2559.1990.tb01111.x [doi]
PST - ppublish
SO  - Histopathology. 1990 Mar;16(3):251-5. doi: 10.1111/j.1365-2559.1990.tb01111.x.