PMID- 16920498
OWN - NLM
STAT- MEDLINE
DCOM- 20061227
LR  - 20060821
IS  - 0171-2985 (Print)
IS  - 0171-2985 (Linking)
VI  - 211
IP  - 6-8
DP  - 2006
TI  - Targeting antigens to dendritic cells in vivo.
PG  - 599-608
AB  - Dendritic cells (DCs) play a key role in antigen-specific immune regulation. DCs 
      take up and process antigens and present these as peptides through MHC molecules 
      to T cells. Recent pre-clinical and clinical studies have exploited DCs as a 
      means to improve vaccine efficiency. In these studies, monocyte-derived 
      autologous DCs are loaded ex vivo with antigens and re-administered to the 
      patient. These tailor-made vaccines are costly and labor intensive, and therefore 
      less suitable for large-scale immunization programs. As a next step in the 
      development of DC vaccines, it is proposed to load DCs with antigens in vivo. 
      Drug delivery systems harboring antigens have been targeted to DCs via specific 
      surface receptors preferentially expressed by DCs, resulting in priming of 
      humoral and cellular immune responses. The present review focuses on the various 
      antigen delivery systems that are currently in use and the DC surface receptors 
      they target.
FAU - Tacken, Paul J
AU  - Tacken PJ
AD  - Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, 
      Radboud University Nijmegen Medical Centre, Nijmegen, 6500 HB Nijmegen, The 
      Netherlands.
FAU - Torensma, Ruurd
AU  - Torensma R
FAU - Figdor, Carl G
AU  - Figdor CG
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20060707
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
RN  - 0 (Antigens)
RN  - 0 (Liposomes)
SB  - IM
MH  - Adenoviridae/immunology
MH  - Animals
MH  - Antigens/*metabolism
MH  - Cross-Priming/immunology
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Humans
MH  - Liposomes/metabolism
RF  - 87
EDAT- 2006/08/22 09:00
MHDA- 2006/12/28 09:00
CRDT- 2006/08/22 09:00
PHST- 2006/08/22 09:00 [pubmed]
PHST- 2006/12/28 09:00 [medline]
PHST- 2006/08/22 09:00 [entrez]
AID - S0171-2985(06)00080-5 [pii]
AID - 10.1016/j.imbio.2006.05.021 [doi]
PST - ppublish
SO  - Immunobiology. 2006;211(6-8):599-608. doi: 10.1016/j.imbio.2006.05.021. Epub 2006 
      Jul 7.