PMID- 16921250
OWN - NLM
STAT- MEDLINE
DCOM- 20070116
LR  - 20061101
IS  - 0304-324X (Print)
IS  - 0304-324X (Linking)
VI  - 52
IP  - 6
DP  - 2006
TI  - The impact of environment in comparison with moderate physical exercise and 
      dietary restriction on BDNF in the cerebral parietotemporal cortex of aged 
      Sprague-Dawley rats.
PG  - 377-81
AB  - BACKGROUND AND AIMS: Moderate physical exercise, dietary restriction as well as 
      enriched environment in separate studies have been reported to delay some of the 
      adverse effects of aging on brain function, parallel to an increase in 
      brain-derived neurotrophic factor (BDNF). In order to elucidate these influences 
      in a comparative setting, we examined the tissue concentrations of BDNF in the 
      cerebral parietotemporal cortex of old Sprague-Dawley rats. METHODS: Male 
      Sprague-Dawley rats were divided randomly into six groups, living from 5 months 
      (baseline group BL) up to 23 months of age as follows: voluntary running in 
      wheels (RW), food restricted by feeding to pair weight with RW animals (PW), 
      forced running on treadmills (TM), and sedentary controls with ad libitum access 
      to food, either housed individually (S1) or in groups of 4 animals (S4). BDNF 
      concentrations were determined by a commercially available ELISA. RESULTS: We 
      found higher BNDF concentrations in the 5 months old animals than in the 23 
      months old animals of group S1. The old sedentary group S4 showed significantly 
      higher BNDF concentrations in comparison with the old individually caged groups 
      RW, TM, PW and S1. Their BNDF concentrations were even higher than those of the 
      young baseline group. CONCLUSIONS: Our data suggest that housing and social 
      interactions have more influence on BDNF concentrations in the cerebral 
      parietotemporal cortex of aging Sprague-Dawley rats than physical exercise and 
      food restriction.
CI  - Copyright (c) 2006 S. Karger AG, Basel.
FAU - Strasser, Alois
AU  - Strasser A
AD  - Institute of Physiology, Department of Natural Sciences, University of Veterinary 
      Medicine Vienna, Vienna, Austria. alois.strasser@vu-wien.ac.at
FAU - Skalicky, Monika
AU  - Skalicky M
FAU - Hansalik, Michaela
AU  - Hansalik M
FAU - Viidik, Andrus
AU  - Viidik A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060817
PL  - Switzerland
TA  - Gerontology
JT  - Gerontology
JID - 7601655
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*analysis
MH  - *Caloric Restriction
MH  - Cerebral Cortex/*metabolism
MH  - *Environment, Controlled
MH  - Housing, Animal
MH  - Male
MH  - Models, Animal
MH  - Physical Conditioning, Animal/*psychology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Social Isolation
EDAT- 2006/08/22 09:00
MHDA- 2007/01/17 09:00
CRDT- 2006/08/22 09:00
PHST- 2006/06/16 00:00 [received]
PHST- 2006/06/26 00:00 [accepted]
PHST- 2006/08/22 09:00 [pubmed]
PHST- 2007/01/17 09:00 [medline]
PHST- 2006/08/22 09:00 [entrez]
AID - 95117 [pii]
AID - 10.1159/000095117 [doi]
PST - ppublish
SO  - Gerontology. 2006;52(6):377-81. doi: 10.1159/000095117. Epub 2006 Aug 17.