PMID- 16921414 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20070719 LR - 20200929 IS - 1554-0766 (Electronic) IS - 1554-0766 (Linking) VI - 5 DP - 2006 Jan 28 TI - Severe desquamating disorder after liver transplant: toxic epidermal necrolysis or graft versus host disease? PG - e1 LID - e1 AB - OBJECTIVE: The objective of this article is to present and discuss the clinical characteristics of TEN (Toxic Epidermal Necrolysis) and GVHD (Graft Versus Host Disease) following orthotopic liver transplantation. METHODS: Recent experience with a patient who suffered a fatal desquamation syndrome within weeks of liver transplantation provides the basis for a discussion of differential diagnosis of these two conditions. RESULTS: TEN and GVHD demonstrate similar clinical presentations as well as etiology (CD8+ lymphocyte attack on epithelial surfaces). This case demonstrates the difficulty in distinguishing between these two conditions in this particular patient. CONCLUSIONS: Advances in the understanding and treatment of one of these disease states may provide therapeutic insights into the other. FAU - Schulz, John T 3rd AU - Schulz JT 3rd AD - Bridgeport Hospital, Bridgeport, CT, USA. pjschu@bpthosp.org FAU - Sheridan, Robert L AU - Sheridan RL LA - eng PT - Journal Article DEP - 20060128 PL - United States TA - J Burns Wounds JT - Journal of burns and wounds JID - 101280410 PMC - PMC1687152 EDAT- 2006/08/22 09:00 MHDA- 2006/08/22 09:01 PMCR- 2006/02/01 CRDT- 2006/08/22 09:00 PHST- 2006/08/22 09:00 [pubmed] PHST- 2006/08/22 09:01 [medline] PHST- 2006/08/22 09:00 [entrez] PHST- 2006/02/01 00:00 [pmc-release] AID - 1 [pii] PST - epublish SO - J Burns Wounds. 2006 Jan 28;5:e1.