PMID- 16922051
OWN - NLM
STAT- MEDLINE
DCOM- 20061012
LR  - 20151119
IS  - 0391-5387 (Print)
IS  - 0391-5387 (Linking)
VI  - 27
IP  - 1-2
DP  - 2005 Jan-Apr
TI  - [G-CSF, neutropenia and candidiasis in VLBW patients].
PG  - 92-7
AB  - OBJECTIVES: Relationships among Early Onset Neutropenia (EON), i.e. neutropenia 
      in the first week of life, treated with Filgrastim, and subsequent colonization 
      by Candida spp. with eventual systemic fungal infection in ELBW patients are not 
      clear. We tried to analyze these features in a retrospective study on a selected 
      population of a large tertiary NICU. METHODS: By a database search, we identified 
      a group of VLBW patients who were diagnosed a systemic fungal infection (SFI) 
      during their stay in NICU (n=52), and divided them in two subgroups: those who 
      had presented Early Onset Neutropenia (EON) and thus had been treated with a 
      3-day course of Filgrastim (n=14)(group A), and those who had not presented EON 
      and thus had not undergone Filgrastim therapy (n=38) (group B). We investigated 
      in both subgroups the following variables: neutrophil count monitoring during the 
      first 2 weeks of life, colonization by Candida spp, day of onset of SFI, outcome. 
      Statistical analysis was performed by Chi-square test, ANOVA and T-test using 
      SPSS 8.0 for Windows. RESULTS: Absolute neutrophil number was obviously lower in 
      group A at recruitment (354/mmc vs 2910\mmc, Chi-square = 9.776, p <0.005), but 
      became normal at the end of G-CSF treatment, thus detecting no significant 
      differences between the two groups at day 8 (p<0.12) and 14 (p<0.34). The onset 
      of SFI occurred significantly earlier ( 9.6 dol vs 14.6 dol., p<0.004) in group A 
      neonates. Fungal Colonization rate in the 2nd week of life was significantly 
      higher in previously neutropenic patients (71% vs. 37%, p< 0.005), who had also a 
      significantly higher number of sites involved (p<0.003). CONCLUSIONS: Neutropenia 
      in the first days of life in VLBW neonates, even if adequately and succesfully 
      treated, heavily influences rates and severity of colonization by fungal spp., 
      and is associated with an earlier onset of a SFI.
FAU - Manzoni, P
AU  - Manzoni P
AD  - Divisione di Neonatologia e TIN Ospedaliera, Az. Osp. Regina Margherita, S. Anna, 
      Torino. paolomanzoni@hotmail.com
FAU - Leonessa, M L
AU  - Leonessa ML
FAU - Monetti, C
AU  - Monetti C
FAU - Galletto, P
AU  - Galletto P
FAU - Gomirato, G
AU  - Gomirato G
LA  - ita
PT  - English Abstract
PT  - Journal Article
TT  - G-CSF, neutropenia e candidiasi nel VLBW.
PL  - Italy
TA  - Pediatr Med Chir
JT  - La Pediatria medica e chirurgica : Medical and surgical pediatrics
JID - 8100625
RN  - 0 (Recombinant Proteins)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
RN  - PVI5M0M1GW (Filgrastim)
SB  - IM
MH  - Candidiasis/*etiology
MH  - Filgrastim
MH  - Granulocyte Colony-Stimulating Factor/*therapeutic use
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Very Low Birth Weight
MH  - Neutropenia/*complications/*drug therapy
MH  - Recombinant Proteins
MH  - Retrospective Studies
EDAT- 2006/08/23 09:00
MHDA- 2006/10/13 09:00
CRDT- 2006/08/23 09:00
PHST- 2006/08/23 09:00 [pubmed]
PHST- 2006/10/13 09:00 [medline]
PHST- 2006/08/23 09:00 [entrez]
PST - ppublish
SO  - Pediatr Med Chir. 2005 Jan-Apr;27(1-2):92-7.