PMID- 1692333
OWN - NLM
STAT- MEDLINE
DCOM- 19900613
LR  - 20191028
IS  - 0174-1578 (Print)
IS  - 0174-1578 (Linking)
VI  - 159
IP  - 6
DP  - 1990
TI  - Neural regulation of the pulmonary vasculature in a semi-arboreal snake, Elaphe 
      obsoleta.
PG  - 677-85
AB  - The innervation of the pulmonary vasculature of the semi-arboreal rat snake, 
      Elaphe obsoleta, was examined with glyoxylic acid-induced catecholamine 
      histochemistry, peptide immunohistochemistry, and in vitro perfusion of the 
      pulmonary vasculature. An adrenergic innervation was present on the pulmonary 
      artery, the smaller pulmonary arteries, the veins draining the lung, and the main 
      pulmonary vein. Vasoactive intestinal polypeptide-like immunoreactive axons were 
      observed on the pulmonary artery and vein, small arteries, and occasionally small 
      veins within the lung parenchyma. A dense plexus of substance P-like 
      immunoreactive (SP-LI) axons was observed on the distal extrinsic pulmonary 
      artery. SP-LI axons were found on the more distal arteries within the lung 
      parenchyma, but not on the veins. The distribution of calcitonin gene-related 
      peptide- and SP-LI axons was similar suggesting that the axons are sensory 
      nerves. In the perfused pulmonary vasculature, vagal stimulation caused a 
      predominant vasoconstriction which was abolished by atropine indicating it was 
      cholinergic in nature. A post-stimulus vasodilatation was abolished by bretylium 
      and propranolol indicating it was adrenergic in nature. The responses to nerve 
      stimulation were located in both the extrinsic and intrinsic pulmonary 
      vasculature. No evidence for non-adrenergic, non-cholinergic transmission to the 
      vascular smooth muscle was found. The extensive, functional innervation of the 
      main pulmonary artery, as well as the more distal vasculature within the lung, 
      may reflect adaptation to cardiovascular problems imposed by an elongated body 
      and arboreal habits.
FAU - Donald, J A
AU  - Donald JA
AD  - Department of Zoology, University of Florida, Gainesville 32611.
FAU - O'Shea, J E
AU  - O'Shea JE
FAU - Lillywhite, H B
AU  - Lillywhite HB
LA  - eng
GR  - HL 33821/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - J Comp Physiol B
JT  - Journal of comparative physiology. B, Biochemical, systemic, and environmental 
      physiology
JID - 8413200
RN  - 0 (Glyoxylates)
RN  - 33507-63-0 (Substance P)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
RN  - 51110-01-1 (Somatostatin)
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
RN  - JQ39C92HH6 (glyoxylic acid)
SB  - IM
MH  - Animals
MH  - Calcitonin Gene-Related Peptide/analysis
MH  - Electric Stimulation
MH  - Fluorescent Antibody Technique
MH  - Glyoxylates
MH  - Histocytochemistry
MH  - Lung/*blood supply/innervation
MH  - Perfusion
MH  - Snakes/*physiology
MH  - Somatostatin/analysis
MH  - Substance P/analysis
MH  - Sympathetic Nervous System/physiology
MH  - Vagus Nerve/physiology
MH  - Vasoactive Intestinal Peptide/analysis
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1007/BF00691713 [doi]
PST - ppublish
SO  - J Comp Physiol B. 1990;159(6):677-85. doi: 10.1007/BF00691713.