PMID- 16923753
OWN - NLM
STAT- MEDLINE
DCOM- 20061024
LR  - 20220317
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Linking)
VI  - 114
IP  - 10
DP  - 2006 Sep 5
TI  - Specific temporal profile of matrix metalloproteinase release occurs in patients 
      after myocardial infarction: relation to left ventricular remodeling.
PG  - 1020-7
AB  - BACKGROUND: Changes in matrix metalloproteinase (MMP) and tissue inhibitors of 
      MMPs (TIMPs) contribute to left ventricular (LV) remodeling after myocardial 
      infarction (MI). We tested the hypothesis that a specific plasma MMP/TIMP profile 
      would emerge after MI and be associated with the degree of LV dilation. METHODS 
      AND RESULTS: LV end-diastolic volume and MMP/TIMP plasma profiles were determined 
      in 53 age-matched control subjects and 32 post-MI patients from day 1 through 180 
      after MI. LV end-diastolic volume increased by > 38% at day 90 after MI (P < 
      0.05). MMP-9 increased by > 150% from control at day 1 after MI (P < 0.05) and 
      remained elevated. MMP-8 rose to > 120% at day 3 after MI (P < 0.05) and fell to 
      control values by day 5. TIMP-1 increased by > 60% from control at day 1 after MI 
      (P < 0.05), whereas TIMP-2 increased only at later time points. Cardiac-specific 
      TIMP-4 fell by 40% at day 5 after MI and remained reduced. A persistent or 
      elevated MMP-9 at day 5 was accompanied by a 3-fold end-diastolic volume increase 
      at day 28 (P < 0.05). CONCLUSIONS: A specific temporal pattern of MMP/TIMPs 
      occurred in post-MI patients that included an early and robust rise in MMP-9 and 
      MMP-8 and a uniform fall in TIMP-4. These findings suggest that a specific 
      MMP/TIMP plasma profile occurs after MI and holds both prognostic and diagnostic 
      significance.
FAU - Webb, Carson S
AU  - Webb CS
AD  - Division of Cardiology, Department of Medicine, Medical University of South 
      Carolina, Charleston, SC 29425, USA.
FAU - Bonnema, David D
AU  - Bonnema DD
FAU - Ahmed, S Hinan
AU  - Ahmed SH
FAU - Leonardi, Amy H
AU  - Leonardi AH
FAU - McClure, Catherine D
AU  - McClure CD
FAU - Clark, Leslie L
AU  - Clark LL
FAU - Stroud, Robert E
AU  - Stroud RE
FAU - Corn, William C
AU  - Corn WC
FAU - Finklea, Laura
AU  - Finklea L
FAU - Zile, Michael R
AU  - Zile MR
FAU - Spinale, Francis G
AU  - Spinale FG
LA  - eng
GR  - MO1-RR-01070-251/RR/NCRR NIH HHS/United States
GR  - P01-HL-48788/HL/NHLBI NIH HHS/United States
GR  - R01-HL-59165/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20060821
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Biomarkers)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2)
RN  - EC 3.4.24.- (Gelatinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Biomarkers/blood
MH  - Electrocardiography
MH  - Female
MH  - Gelatinases/blood
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinases/*blood
MH  - Middle Aged
MH  - Myocardial Infarction/blood/drug therapy/*enzymology
MH  - Reference Values
MH  - Thrombolytic Therapy
MH  - Tissue Inhibitor of Metalloproteinase-1/blood
MH  - Tissue Inhibitor of Metalloproteinase-2/blood
MH  - Ventricular Remodeling/physiology
EDAT- 2006/08/23 09:00
MHDA- 2006/10/25 09:00
CRDT- 2006/08/23 09:00
PHST- 2006/08/23 09:00 [pubmed]
PHST- 2006/10/25 09:00 [medline]
PHST- 2006/08/23 09:00 [entrez]
AID - CIRCULATIONAHA.105.600353 [pii]
AID - 10.1161/CIRCULATIONAHA.105.600353 [doi]
PST - ppublish
SO  - Circulation. 2006 Sep 5;114(10):1020-7. doi: 10.1161/CIRCULATIONAHA.105.600353. 
      Epub 2006 Aug 21.