PMID- 16924692
OWN - NLM
STAT- MEDLINE
DCOM- 20070220
LR  - 20191210
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 33
IP  - 10
DP  - 2006 Oct
TI  - Health assessment questionnaire score is the best predictor of 5-year quality of 
      life in early rheumatoid arthritis.
PG  - 1936-41
AB  - OBJECTIVE: To evaluate and determine prognostic factors of 5-year quality of life 
      in patients with early rheumatoid arthritis (RA). METHODS: A cohort of 191 
      patients with RA and disease duration < 1 year was prospectively followed over 5 
      years. The outcome measure was quality of life as assessed by the Arthritis 
      Impact Measurement Scales 2 (AIMS2). Univariate analysis, then stepwise multiple 
      logistic regression, was used to find independent baseline prognostic variables. 
      RESULTS: After accounting for death, loss of followup, and missing data, 158 
      patients (82.72%) were included in the analysis. The mean AIMS2 physical, 
      symptom, psychological, social interaction, and work scores after 5 years were 
      1.6 (range 0-6.88), 4.0 (0-10), 3.48 (0-9.22), 4.06 (0-8.69), and 1.87 (0-8.13), 
      respectively. The AIMS2 physical component was significantly correlated with 
      Health Assessment Questionnaire (HAQ) score at 5 years. Logistic regression 
      analysis revealed that the baseline values able to predict the 5-year physical, 
      psychological, symptom, social interaction, and work status were, respectively: 
      HAQ score and erythrocyte sedimentation rate (ESR), body mass index (BMI), HAQ; 
      erosion score and sex, HAQ; ESR and anti-perinuclear antibody; matrix 
      metalloproteinase-3 (MMP3) level, joint space narrowing, and tender joint scores; 
      HAQ score and age. CONCLUSION: The multidimensional structure of the AIMS2 
      allowed us to assess the 5-year health-related quality of life in early RA. Using 
      this instrument as an outcome variable, prognostic factors were selected and 
      varied widely depending on the evaluated domain. The baseline HAQ score was the 
      best predictive factor of 4 of the 5 domains of the AIMS2.
FAU - Cohen, Jean-David
AU  - Cohen JD
AD  - Department of Immuno-Rhumatologie, CHU Montpellier, Montpellier I University and 
      INSERM U454, Montpellier, France.
FAU - Dougados, Maxime
AU  - Dougados M
FAU - Goupille, Philippe
AU  - Goupille P
FAU - Cantagrel, Alain
AU  - Cantagrel A
FAU - Meyer, Olivier
AU  - Meyer O
FAU - Sibilia, Jean
AU  - Sibilia J
FAU - Daures, Jean-Pierre
AU  - Daures JP
FAU - Combe, Bernard
AU  - Combe B
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20060815
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Antirheumatic Agents)
SB  - IM
CIN - Nat Clin Pract Rheumatol. 2007 Jul;3(7):380-1. PMID: 17549087
MH  - Adult
MH  - Antirheumatic Agents/therapeutic use
MH  - Arthritis, Rheumatoid/*complications/diagnostic imaging/drug therapy/*psychology
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - *Outcome Assessment, Health Care
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Radiography
MH  - Severity of Illness Index
MH  - *Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2006/08/23 09:00
MHDA- 2007/02/21 09:00
CRDT- 2006/08/23 09:00
PHST- 2006/08/23 09:00 [pubmed]
PHST- 2007/02/21 09:00 [medline]
PHST- 2006/08/23 09:00 [entrez]
AID - 06/13/0813 [pii]
PST - ppublish
SO  - J Rheumatol. 2006 Oct;33(10):1936-41. Epub 2006 Aug 15.