PMID- 16925098
OWN - NLM
STAT- MEDLINE
DCOM- 20061004
LR  - 20151119
IS  - 0120-4157 (Print)
IS  - 0120-4157 (Linking)
VI  - 26
IP  - 2
DP  - 2006 Jun
TI  - Serum levels of insulin-like growth factor-I and -II and insulin-like growth 
      factor binding protein 3 in women with squamous intraepithelial lesions and 
      cervical cancer.
PG  - 258-68
AB  - INTRODUCTION: Pap smear has limitations as a screening test for cervical cancer. 
      A marker that allows the identification of women who are at risk of developing 
      cervical cancer would be useful for its prevention. A growing number of studies 
      have demonstrated an association between insulin-like growth factors (IGF) serum 
      levels and increased risk for various cancers. Objective. To assess whether 
      circulating IGF-I, IGF-II, or IGF binding protein 3 (IGFBP-3) were associated 
      with cervical cancer and low-grade and high-grade squamous intraepithelial 
      lesions (LSIL and HSIL). MATERIALS AND METHODS: Serum levels of IGF-I, IGF-II and 
      IGFBP-3 were measured by ELISA. Three groups of cases were analyzed: LSIL (n = 
      37), HSIL (n = 57), and cervical cancer (n = 41). For each case, two controls, 
      matched by age, were included. Control subjects were women with normal, 
      HPV-DNA-negative Pap smear. RESULTS: Significantly lower values of IGF-I (83.9 
      ng/ml versus 126.6 ng/ml, p < 0.001) and IGF-I:IGFBP-3 molar ratio (0.094 versus 
      0.137, p < 0.001) were observed among cancer cases, as compared to their control 
      group. Women in the highest quartile of IGF-I and IGF-I:IGFBP-3 molar ratio were 
      at an 80% (OR = 0.2, 95% CI [0.06-0.61]) and a 77% (OR = 0.23, 95% CI 
      [0.07-0.73]) lower risk of cervical cancer, respectively, compared with women in 
      the corresponding reference category. CONCLUSIONS: These data suggest that low 
      values of IGF-I and IGF-I:IGFBP-3 molar ratio may be associated with cervical 
      cancer.
FAU - Serrano, Martha Lucia
AU  - Serrano ML
AD  - Grupo de Investigacion en Biologia del Cancer, Instituto Nacional de 
      Cancerologia, Bogota D.C., Colombia. mserrano@incancerologia.gov.co
FAU - Romero, Alfredo
AU  - Romero A
FAU - Cendales, Ricardo
AU  - Cendales R
FAU - Sanchez-Gomez, Myriam
AU  - Sanchez-Gomez M
FAU - Bravo, Maria Mercedes
AU  - Bravo MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Colombia
TA  - Biomedica
JT  - Biomedica : revista del Instituto Nacional de Salud
JID - 8205605
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
SB  - IM
MH  - Adult
MH  - Biomarkers, Tumor/metabolism
MH  - Case-Control Studies
MH  - Colombia
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Insulin-Like Growth Factor II/*metabolism
MH  - Neoplasms, Squamous Cell/*blood/diagnosis/pathology
MH  - Odds Ratio
MH  - Papillomaviridae/metabolism
MH  - Risk Factors
MH  - Uterine Cervical Neoplasms/*blood/diagnosis/pathology
EDAT- 2006/08/24 09:00
MHDA- 2006/10/05 09:00
CRDT- 2006/08/24 09:00
PHST- 2006/08/24 09:00 [pubmed]
PHST- 2006/10/05 09:00 [medline]
PHST- 2006/08/24 09:00 [entrez]
PST - ppublish
SO  - Biomedica. 2006 Jun;26(2):258-68.