PMID- 16925688
OWN - NLM
STAT- MEDLINE
DCOM- 20061106
LR  - 20151119
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 17
IP  - 6
DP  - 2006 Sep
TI  - Airway hyper-responsiveness to adenosine 5'-monophosphate in preschool-age 
      children with asthma.
PG  - 428-34
AB  - Airway hyper-responsiveness (AHR) to adenosine 5'-monophosphate (AMP) is closely 
      associated with airway inflammation; however, not all asthmatic patients are 
      responsive to it. This study was planned to investigate the predictive factors of 
      AHR to AMP in asthmatic children aged between 3 and 6 yr. We performed a 
      retrospective analysis of data from 63 asthmatic preschool-age children who were 
      challenged by AMP in our department. All children were characterized by 
      skin-prick tests, serum immunoglobulin E (IgE) levels, peripheral blood 
      eosinophil percentage and bronchial challenge with methacholine (MCH) and AMP. 
      Potential determinants for AHR to AMP were assessed within the group. AHR to AMP 
      was found in 46% of preschool-age children with asthma, while that of MCH was 
      93.7%. All children responsive to AMP were also responsive to MCH. The geometric 
      mean provocative concentration of MCH and AMP causing a 15% fall in 
      transcutaneous oxygen tension (PC(15)PtcO(2)MCH and AMP) were 0.55 mg/ml 
      (0.004-9.19) and 10.53 mg/ml (0.59-342.89), respectively. AMP-responsive children 
      did not differ from non-responsive ones with respect to demographic factors, 
      geometric mean PC(15)PtcO(2)MCH and atopic status. The median serum IgE level was 
      significantly higher in AMP-responsive group than the non-responsive ones (p = 
      0.011). The peripheral blood eosinophilia was more frequent among responsive 
      children (p = 0.019), and it was found as the only predictive factor for AMP 
      responsiveness in preschool-age children with asthma in logistic regression model 
      (odds ratio: 5.14; 95% CI: 1.23-21.47; p = 0.025). AMP responsiveness may be 
      predicted by peripheral blood eosinophilia but not with atopy markers in young 
      children with asthma.
FAU - Bakirtas, Arzu
AU  - Bakirtas A
AD  - Gazi University, Faculty of Medicine, Department of Pediatric Allergy and Asthma, 
      Ankara, Turkey. arzub@gazi.edu.tr
FAU - Turktas, Ipek
AU  - Turktas I
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Bronchoconstrictor Agents)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 415SHH325A (Adenosine Monophosphate)
SB  - IM
MH  - *Adenosine Monophosphate
MH  - Asthma/blood/immunology/*physiopathology
MH  - Blood Gas Monitoring, Transcutaneous
MH  - Bronchial Hyperreactivity/blood/*diagnosis/immunology
MH  - Bronchial Provocation Tests
MH  - *Bronchoconstrictor Agents
MH  - Child, Preschool
MH  - Eosinophils/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Male
MH  - Methacholine Chloride
MH  - Skin Tests
EDAT- 2006/08/24 09:00
MHDA- 2006/11/07 09:00
CRDT- 2006/08/24 09:00
PHST- 2006/08/24 09:00 [pubmed]
PHST- 2006/11/07 09:00 [medline]
PHST- 2006/08/24 09:00 [entrez]
AID - PAI411 [pii]
AID - 10.1111/j.1399-3038.2006.00411.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2006 Sep;17(6):428-34. doi: 
      10.1111/j.1399-3038.2006.00411.x.