PMID- 16926975
OWN - NLM
STAT- MEDLINE
DCOM- 20070322
LR  - 20070621
IS  - 1684-1182 (Print)
IS  - 1684-1182 (Linking)
VI  - 39
IP  - 4
DP  - 2006 Aug
TI  - Association between angiotensin-converting enzyme gene polymorphism and childhood 
      allergic rhinitis in Taiwan.
PG  - 297-301
AB  - BACKGROUND AND PURPOSE: Angiotensin-converting enzyme (ACE) play a role in 
      inactivating bradykinin and tachykinins. Bradykinin and tachykinins are potent 
      mediators of inflammatory reaction. An insertion/deletion polymorphism of the ACE 
      gene has been shown to be associated with serum ACE levels. We hypothesized that 
      ACE polymorphism might play a role in allergic rhinitis development. METHODS: 
      Seventy five children aged 6-13 years with atopic allergic rhinitis and 66 age- 
      and gender-matched healthy children were studied. ACE genotypes were determined 
      by polymerase chain reaction. Serum total immunoglobulin E (IgE) and 
      allergen-specific IgE levels were also measured. RESULTS: The frequencies of the 
      DD and non-DD genotypes, and of the II and non-II genotypes did not differ 
      significantly between healthy children and allergic rhinitis children 
      (chi-squared test, p=1.000 and 0.438, respectively). There was no association of 
      ACE genotype and mean IgE levels in rhinitis children or healthy controls. 
      CONCLUSION: The results of our study indicate that polymorphism of the ACE gene 
      is unrelated to the development of allergic rhinitis, the duration of allergic 
      rhinitis, serum IgE levels, and allergen-specific IgE in Taiwanese children.
FAU - Ku, Min-Sho
AU  - Ku MS
AD  - Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chung 
      Shan Medical University Hospital, Taichung, Taiwan.
FAU - Lue, Ko-Huang
AU  - Lue KH
FAU - Li, Ching
AU  - Li C
FAU - Sun, Hai-Lun
AU  - Sun HL
FAU - Chou, Ming-Chih
AU  - Chou MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Child
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Peptidyl-Dipeptidase A/*genetics/metabolism
MH  - Polymorphism, Genetic
MH  - Rhinitis, Allergic, Perennial/*enzymology/*genetics/immunology
MH  - Taiwan
EDAT- 2006/08/24 09:00
MHDA- 2007/03/23 09:00
CRDT- 2006/08/24 09:00
PHST- 2006/08/24 09:00 [pubmed]
PHST- 2007/03/23 09:00 [medline]
PHST- 2006/08/24 09:00 [entrez]
PST - ppublish
SO  - J Microbiol Immunol Infect. 2006 Aug;39(4):297-301.