PMID- 16926978
OWN - NLM
STAT- MEDLINE
DCOM- 20070322
LR  - 20070621
IS  - 1684-1182 (Print)
IS  - 1684-1182 (Linking)
VI  - 39
IP  - 4
DP  - 2006 Aug
TI  - Higher incidence of Dermatophagoides pteronyssinus allergy in children of Taipei 
      city than in children of rural areas.
PG  - 316-20
AB  - BACKGROUND AND PURPOSE: House dust mites are the most common cause of 
      sensitization in wheezing children in most parts of the world. The aim of this 
      study was to investigate prevalence of sensitization and the levels of specific 
      immunoglobulin E (IgE) to Dermatophagoides pteronyssinus (Der p) in wheezing 
      children in Taipei city and central rural Taiwan. METHODS: A total of 3546 
      children were enrolled in this study. Children were grouped into those living in 
      Taipei city (n = 1340) and those residing in the rural part of central Taiwan 
      (2206). The prevalence of sensitization and level of specific IgE antibody to Der 
      p and cockroach were analyzed by age and geographic area. RESULTS: The results 
      showed significantly higher sensitization rates and mean specific IgE levels to 
      Der p with increasing age of patients in both Taipei city and rural central 
      Taiwan. In addition, children from Taipei city had a significantly higher average 
      sensitization rate of Der p than rural children (p<0.05). The proportion of 
      children sensitized to cockroach increased with age both in Taipei city and 
      central rural Taiwan, but the specific IgE levels to cockroach were not 
      statistically different between the 2 groups (p=0.061). CONCLUSIONS: Sensitivity 
      to aeroallergens varies with age and with geographical location (city vs rural) 
      in asthmatic children. Circulating IgE antibodies against Der p were common at 
      all ages. Cockroach allergen is also associated with recurrent wheezing in 
      Taiwan. Avoidance of indoor aeroallergens such as Der p and cockroach allergen 
      should be an important component in plans for the management of recurrent 
      wheezing.
FAU - Chang, Jei-Wen
AU  - Chang JW
AD  - Department of Pediatrics, Tao-Yuan Veterans Hospital and Taipei Veterans General 
      Hospital, and Institute of Clinical Medicine, National Yang-Ming University, 
      Taipei, Taiwan.
FAU - Lin, Ching-Yuang
AU  - Lin CY
FAU - Chen, Woan-Ling
AU  - Chen WL
FAU - Chen, Ching-Tung
AU  - Chen CT
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Microbiol Immunol Infect
JT  - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
JID - 100956211
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antibody Specificity
MH  - Child
MH  - Child, Preschool
MH  - Cockroaches/immunology
MH  - Dermatophagoides pteronyssinus/*immunology
MH  - Humans
MH  - Hypersensitivity/*epidemiology/immunology
MH  - Immunoglobulin E/immunology
MH  - Incidence
MH  - Infant
MH  - Respiratory Sounds/immunology
MH  - Taiwan/epidemiology
EDAT- 2006/08/24 09:00
MHDA- 2007/03/23 09:00
CRDT- 2006/08/24 09:00
PHST- 2006/08/24 09:00 [pubmed]
PHST- 2007/03/23 09:00 [medline]
PHST- 2006/08/24 09:00 [entrez]
PST - ppublish
SO  - J Microbiol Immunol Infect. 2006 Aug;39(4):316-20.