PMID- 1692987
OWN - NLM
STAT- MEDLINE
DCOM- 19900625
LR  - 20180216
IS  - 0030-3747 (Print)
IS  - 0030-3747 (Linking)
VI  - 22
IP  - 2
DP  - 1990
TI  - Clinical patterns of ocular anaphylaxis in guinea pigs passively sensitized with 
      IgG1 antibody.
PG  - 95-105
AB  - A model of topically induced ocular anaphylaxis in guinea pigs was developed. A 
      guinea pig anti-dinitrophenyl (DNP) bovine gamma-globulin antiserum rich in IgG1 
      antibodies was injected subconjunctivally; various serum dilutions and latent 
      periods were tested. The anaphylactic response was elicited with di-DNP-lysine 
      applied topically. The response was characterized by rating 11 ocular signs. 
      Although the 4-hour latent period is considered optimal for passive cutaneous 
      anaphylaxis, a 14-hour latent period yielded the strongest ocular reaction and 
      appeared to the most appropriate time for clinical assessment. Both an 
      early-phase reaction (peaking in the 21st hour) and a late-phase reaction 
      (peaking at 6-10 h) were observed. The two signs of the early-phase reaction that 
      recurred in the late-phase reaction were periorbital swelling and lid redness. 
      The anaphylactic reaction displayed different patterns in different animals: 
      protracted, biphasic and multiphasic.
FAU - Leonardi, A
AU  - Leonardi A
AD  - Immunology Unit, Eye Research Institute, Boston, Mass.
FAU - Briggs, R M
AU  - Briggs RM
FAU - Bloch, K J
AU  - Bloch KJ
FAU - Allansmith, M R
AU  - Allansmith MR
LA  - eng
GR  - EY07733/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Ophthalmic Res
JT  - Ophthalmic research
JID - 0267442
RN  - 0 (Immunoglobulin G)
RN  - 0 (dinitrophenyl gamma globulin)
RN  - 0 (gamma-Globulins)
SB  - IM
MH  - Anaphylaxis/etiology/*immunology
MH  - Animals
MH  - Conjunctiva/metabolism
MH  - Conjunctival Diseases/*immunology
MH  - Disease Models, Animal
MH  - Eyelid Diseases/*immunology
MH  - Female
MH  - Guinea Pigs
MH  - Hypersensitivity, Immediate/immunology
MH  - *Immunization, Passive
MH  - Immunoglobulin G
MH  - Orbital Diseases/*immunology
MH  - gamma-Globulins
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1159/000267007 [doi]
PST - ppublish
SO  - Ophthalmic Res. 1990;22(2):95-105. doi: 10.1159/000267007.