PMID- 16930436
OWN - NLM
STAT- MEDLINE
DCOM- 20070306
LR  - 20181113
IS  - 0953-816X (Print)
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 24
IP  - 4
DP  - 2006 Aug
TI  - Brain-derived neurotrophic factor and neurotrophin receptors modulate 
      glutamate-induced phase shifts of the suprachiasmatic nucleus.
PG  - 1109-16
AB  - Light information reaches the suprachiasmatic nucleus (SCN) through a 
      subpopulation of retinal ganglion cells. Previous work raised the possibility 
      that brain-derived neurotrophic factor (BDNF) and its high-affinity 
      tropomyosin-related receptor kinase may be important as modulators of this 
      excitatory input into the SCN. In order to test this possibility, we used 
      whole-cell patch-clamp methods to measure spontaneous excitatory currents in 
      mouse SCN neurons. We found that the amplitude and frequency of these currents 
      were increased by BDNF and decreased by the neurotrophin receptor inhibitor 
      K252a. The neurotrophin also increased the magnitude of currents evoked by 
      application of N-methyl-d-aspartate and amino-methyl proprionic acid. Next, we 
      measured the rhythms in action potential discharge from the SCN brain slice 
      preparation. We found that application of K252a dramatically reduced the 
      magnitude of phase shifts of the electrical activity rhythm generated by the 
      application of glutamate. By itself, BDNF caused phase shifts that resembled 
      those produced by glutamate and were blocked by K252a. The results demonstrate 
      that BDNF and neurotrophin receptors can enhance glutamatergic synaptic 
      transmission within a subset of SCN neurons and potentiate glutamate-induced 
      phase shifts of the circadian rhythm of neural activity in the SCN.
FAU - Michel, S
AU  - Michel S
AD  - Department of Psychiatry and Biobehavioral Sciences, University of California, 
      Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024-1759, USA.
FAU - Clark, J P
AU  - Clark JP
FAU - Ding, J M
AU  - Ding JM
FAU - Colwell, C S
AU  - Colwell CS
LA  - eng
GR  - R01 NS047014/NS/NINDS NIH HHS/United States
GR  - R01 HL064582/HL/NHLBI NIH HHS/United States
GR  - NS47014/NS/NINDS NIH HHS/United States
GR  - NS043169/NS/NINDS NIH HHS/United States
GR  - R01 HL064582-04/HL/NHLBI NIH HHS/United States
GR  - R01 NS043169/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbazoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Indole Alkaloids)
RN  - 0 (Receptors, Glutamate)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 77521-29-0 (alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid)
RN  - 97161-97-2 (staurosporine aglycone)
SB  - IM
MH  - Animals
MH  - Biological Clocks/physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Carbazoles/metabolism
MH  - Circadian Rhythm/*physiology
MH  - Enzyme Inhibitors/metabolism
MH  - Excitatory Postsynaptic Potentials/physiology
MH  - Glutamic Acid/*metabolism
MH  - Indole Alkaloids
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - N-Methylaspartate/metabolism
MH  - Neurons/cytology/metabolism
MH  - Patch-Clamp Techniques
MH  - Receptors, Glutamate/metabolism
MH  - Receptors, Nerve Growth Factor/antagonists & inhibitors/*metabolism
MH  - Suprachiasmatic Nucleus/cytology/*metabolism
MH  - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/metabolism
PMC - PMC2582382
MID - NIHMS73183
EDAT- 2006/08/26 09:00
MHDA- 2007/03/07 09:00
PMCR- 2008/11/12
CRDT- 2006/08/26 09:00
PHST- 2006/08/26 09:00 [pubmed]
PHST- 2007/03/07 09:00 [medline]
PHST- 2006/08/26 09:00 [entrez]
PHST- 2008/11/12 00:00 [pmc-release]
AID - EJN4972 [pii]
AID - 10.1111/j.1460-9568.2006.04972.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2006 Aug;24(4):1109-16. doi: 10.1111/j.1460-9568.2006.04972.x.