PMID- 16931869
OWN - NLM
STAT- MEDLINE
DCOM- 20070123
LR  - 20220410
IS  - 0022-0345 (Print)
IS  - 0022-0345 (Linking)
VI  - 85
IP  - 9
DP  - 2006 Sep
TI  - Immobilization stress induces BDNF in rat submandibular glands.
PG  - 844-8
AB  - Brain-derived neurotrophic factor (BDNF) promotes survival and differentiation of 
      the cells of the central and peripheral nervous systems. BDNF has been identified 
      in non-neural tissue, including the heart, lung, platelets, lymphocytes, and 
      lacrimal glands. Immobilization stress modifies BDNF mRNA expression in some 
      organs. The present study examines the effect of immobilization stress on BDNF, 
      and its receptor TrkB, in male rat submandibular glands. Increased BDNF mRNA and 
      protein expression were observed in duct cells as a result of immobilization 
      stress, as demonstrated by real-time PCR, Western blot, immunohistochemistry, and 
      analysis by microdissection. TrkB mRNA was not detected in salivary gland tissue, 
      or oral or esophageal mucosa, by RT-PCR. Rat submandibular gland was thus 
      identified as an organ which expresses BDNF. Furthermore, the results of this 
      study suggest that increased salivary BDNF expression occurs following 
      immobilization stress.
FAU - Tsukinoki, K
AU  - Tsukinoki K
AD  - Department of Diagnostic Science, Division of Pathology, Kanagawa Dental College, 
      82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan. ktsukino@kdcnet.ac.jp
FAU - Saruta, J
AU  - Saruta J
FAU - Sasaguri, K
AU  - Sasaguri K
FAU - Miyoshi, Y
AU  - Miyoshi Y
FAU - Jinbu, Y
AU  - Jinbu Y
FAU - Kusama, M
AU  - Kusama M
FAU - Sato, S
AU  - Sato S
FAU - Watanabe, Y
AU  - Watanabe Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Immobilization/*physiology
MH  - Immunohistochemistry
MH  - Male
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Saliva/chemistry
MH  - Salivary Ducts/metabolism
MH  - Stress, Physiological/*metabolism
MH  - Submandibular Gland/*metabolism
MH  - Up-Regulation
EDAT- 2006/08/26 09:00
MHDA- 2007/01/24 09:00
CRDT- 2006/08/26 09:00
PHST- 2006/08/26 09:00 [pubmed]
PHST- 2007/01/24 09:00 [medline]
PHST- 2006/08/26 09:00 [entrez]
AID - 85/9/844 [pii]
AID - 10.1177/154405910608500913 [doi]
PST - ppublish
SO  - J Dent Res. 2006 Sep;85(9):844-8. doi: 10.1177/154405910608500913.