PMID- 16933274
OWN - NLM
STAT- MEDLINE
DCOM- 20061128
LR  - 20090112
IS  - 1545-5009 (Print)
IS  - 1545-5009 (Linking)
VI  - 47
IP  - 5 Suppl
DP  - 2006 Oct 15
TI  - Mechanisms of action of intravenous immunoglobulin in the treatment of immune 
      thrombocytopenia.
PG  - 710-3
AB  - Intravenous immunoglobulin (IVIG) is currently used to treat a multitude of 
      autoimmune disorders including immune thrombocytopenic purpura (ITP), yet the 
      mechanism of action of IVIG remains unresolved. Using a murine model of ITP in 
      which IVIG functions therapeutically, our laboratory has addressed such theories 
      as blockade/inhibition of the mononuclear phagocytic system, cytokine regulation, 
      and neutralization of pathogenic autoantibodies mediated by anti-idiotypic 
      antibodies, and these findings will be discussed herein. We have also 
      demonstrated that soluble immune complexes can completely recapitulate the 
      therapeutic effects of IVIG in ITP, and recent work from us has identified 
      activating Fcgamma receptors on CD11c+ dendritic cells as the relevant molecular 
      target of IVIG in the acute resolution of murine immune thrombocytopenia. This 
      and other work to devise antibody-based IVIG alternative therapies will also be 
      addressed.
CI  - Copyright (c) 2006 Wiley-Liss, Inc.
FAU - Crow, Andrew R
AU  - Crow AR
AD  - The Canadian Blood Services, Department of Laboratory Medicine, St Michael's 
      Hospital and University of Toronto, Ontario, Canada.
FAU - Song, Seng
AU  - Song S
FAU - Siragam, Vinayakumar
AU  - Siragam V
FAU - Lazarus, Alan H
AU  - Lazarus AH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
RN  - 0 (Antigen-Antibody Complex)
RN  - 0 (Autoantibodies)
RN  - 0 (Fcgr2b protein, mouse)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Receptors, IgG)
SB  - IM
MH  - Animals
MH  - Antigen-Antibody Complex/therapeutic use
MH  - Autoantibodies/blood/immunology
MH  - Disease Models, Animal
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Mice
MH  - Purpura, Thrombocytopenic, Idiopathic/immunology/*therapy
MH  - Receptors, IgG/antagonists & inhibitors/immunology
RF  - 34
EDAT- 2006/08/26 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/08/26 09:00
PHST- 2006/08/26 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/08/26 09:00 [entrez]
AID - 10.1002/pbc.20980 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2006 Oct 15;47(5 Suppl):710-3. doi: 10.1002/pbc.20980.