PMID- 16933659
OWN - NLM
STAT- MEDLINE
DCOM- 20060926
LR  - 20191210
IS  - 0033-2941 (Print)
IS  - 0033-2941 (Linking)
VI  - 98
IP  - 3
DP  - 2006 Jun
TI  - An examination of the effects of 5-Methoxy-n, n-di(ISO)propyltryptamine 
      hydrochloride (Foxy) on cognitive development in rats.
PG  - 651-61
AB  - The hallucinogenic "designer drug" known as Foxy or Methoxy Foxy and formally 
      know as 5-Methoxy-N,N-di(iso)propyltryptamine hydrochloride (5-MeO-DIPT) is 
      rapidly gaining popularity among recreational users. However, little is known 
      about the consequences of its use on neuropsychological development or behavior. 
      During one of two adolescent periods, the rats were given repeated injections of 
      either saline or 5 mg/kg of 5-MeO-DIPT. Once the animals reached 80 days of age, 
      they were trained and tested on a number of tasks designed to assess the effects 
      of 5-MeO-DIPT, if any, on memory tasks with spatial components that presumably 
      involve declarative memory systems and on a nonspatial task that is considered 
      sensitive to disruptions in nondeclarative memory. With one exception, both the 
      5-MeO-DIPT- and saline-treated rats were able to master the spatial navigation 
      tests at comparable rates. However, the performance of the drug-treated rats was 
      markedly inferior to that of the control animals on a response-learning task, 
      suggesting a lack of flexibility in adapting their responses to changing task 
      demands. This could indicate reductions in serotonin activity in the forebrain 
      similar to the effects of studied drugs such as methylenedioxymethamphetamine 
      (MDMA), suggesting 5-MeO-DIPT may act as a toxin compromising serotoninergic 
      systems in the brain.
FAU - Compton, David M
AU  - Compton DM
AD  - Donnelley Behavioral Neuroscience Laboratory, Palm Beach Atlantic University, 
      P.O. Box 24708, West Palm Beach, FL 33416-4708, USA. David_Compton@pba.edu
FAU - Selinger, Melissa C
AU  - Selinger MC
FAU - Testa, Erin K
AU  - Testa EK
FAU - Larkins, Krystal D
AU  - Larkins KD
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Psychol Rep
JT  - Psychological reports
JID - 0376475
RN  - 12D06G8W8E (5-methoxy-N,N-diisopropyltryptamine)
RN  - 3VMW6141KC (5-Methoxytryptamine)
SB  - IM
MH  - 5-Methoxytryptamine/administration & dosage/*analogs & derivatives/toxicity
MH  - Animals
MH  - Cognition/*drug effects
MH  - Perceptual Disorders/chemically induced
MH  - Random Allocation
MH  - Rats
MH  - Rats, Long-Evans
MH  - Space Perception/drug effects
EDAT- 2006/08/29 09:00
MHDA- 2006/09/27 09:00
CRDT- 2006/08/29 09:00
PHST- 2006/08/29 09:00 [pubmed]
PHST- 2006/09/27 09:00 [medline]
PHST- 2006/08/29 09:00 [entrez]
AID - 10.2466/pr0.98.3.651-661 [doi]
PST - ppublish
SO  - Psychol Rep. 2006 Jun;98(3):651-61. doi: 10.2466/pr0.98.3.651-661.